Increased Expression of Chitinase 3-Like 1 in Aorta of Patients with Atherosclerosis and Suppression of Atherosclerosis in Apolipoprotein E-Knockout Mice by Chitinase 3-Like 1 Gene Silencing
Figure 1
(a) Immunohistochemical staining of CHI3L1 on sections of arterial vessels in control group and research group. The expression of CHI3L1 was increased in the arterial specimens of CAD patients in research group. () (b) Western blot analysis and quantification of CHI3L1 protein expression in control group and research group. The levels of CHI3L1 protein expression were higher in research group than in control group. versus control group. (c) Quantitative analysis of arterial CHI3L1 expression in research group patients according to gender, smoking, hypertension, and diabetes mellitus. The expression levels of CHI3L1 were elevated in smokers and patients with hypertension or diabetes mellitus, whereas gender had no significant effect. . (d) Relationship between arterial CHI3L1 expression and coronary severity scores. The arterial CHI3L1 expression levels were significantly correlated with coronary severity Gensini scores. Each point represents one patient.
