The Functional Polymorphisms of miR-146a Are Associated with Susceptibility to Severe Sepsis in the Chinese Population

Table 3

Genotype and allele frequencies distribution in different sepsis status and healthy controls.

Genotype	Healthy control 𝑁 (%)	Sepsis (subtype) 𝑁 (%)	Septic shock 𝑁 (%)	Severe sepsis 𝑁 (%)	𝑃 value			𝑃 value*
					𝑃1	𝑃2	𝑃3	𝑃1^∗	𝑃2^∗	𝑃3^∗
rs2910164
Total	206	34	65	127	0.712	0.888	0.0045	0.712	0.888	0.0045
CC	101 (49.03)	15 (44.12)	31 (47.69)	42 (33.07)
GG/GC	105 (50.97)	19 (55.88)	34 (52.31)	85 (66.93)
Allele
C	295 (71.60)	46 (67.65)	91 (70.00)	153 (60.24)
G	117 (28.40)	22 (32.35)	39 (30.00)	101 (39.76)	0.564	0.740	0.0029	0.712	0.888	0.0045
rs57095329
Total	205	33	62	127	0.560	0.278	0.413	0.613	0.503	0.421
AA	135 (65.85)	20 (60.61)	46 (74.19)	78 (61.42)
GG/GA	70 (34.15)	13 (39.39)	16 (25.81)	49 (38.58)
Allele
A	334 (81.46)	52 (78.79)	105 (84.68)	200 (78.74)
G	76 (18.54)	14 (21.21)	19 (15.32)	54 (21.26)	0.613	0.503	0.421	0.613	0.503	0.421

OR: odds ratio; 95% CI: 95% confidence interval. *False discovery rate-adjusted 𝑃 value for multiple hypotheses testing using the Benjamini-Hochberg method. 𝑃₁ and 𝑃₁^∗: healthy control group versus sepsis group. 𝑃₂ and 𝑃₂^∗: healthy control group versus septic shock group. 𝑃₃ and 𝑃₃^∗: healthy control group versus severe sepsis group. Fisher’s exact test 𝑃₃=0.0045, OR = 1.947, 95% CI (1.229–3.083) for genotype in rs2910164; 𝑃₃=0.0029, OR = 1.664, 95% CI (1.196–2.316) for allele in rs2910164.