Inhibition of Age-Related Cytokines Production by ATGL: A Mechanism Linked to the Anti-Inflammatory Effect of Resveratrol

<table>Schematic representation of the ATGL-dependent anti-inflammatory action of resveratrol. Aged adipocytes are characterized by impaired ATGL/FA/PPAR<i>α</i> signalling pathways and by the production of proinflammatory cytokines (TNF<i>α</i> and IL-6). Resveratrol induces ATGL upregulation, activating FA-mediated PPAR<i>α</i> anti-inflammatory effect. ATGL: adipose triglyceride lipase; FA: fatty acid; IL-6: interleukin 6; LD: lipid droplet; NF<i>κ</i>B: uclear factor kappa beta; PPAR<i>α</i>: peroxisome proliferator activated receptor <i>α</i>.</table>

Mediators of Inflammation

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Figure 4

Figure 4: Inhibition of Age-Related Cytokines Production by ATGL: A Mechanism Linked to the Anti-Inflammatory Effect of Resveratrol 