Trypanosoma cruzi Infection in Genetically Selected Mouse Lines: Genetic Linkage with Quantitative Trait Locus Controlling Antibody Response

Table 1

Significance of cosegregation between mortality and survival time traits with microsatellites markers of Ab regulating QTLs (quantitative trait loci) from Selection III or with candidate region markers of T. cruzi infection susceptibility.

Cosegregation test				Trait
Males and females Bc-L				Mortality	Survival time^d
Chrom.	Marker	Location		LRS^c	LRS^c
		(Mb)^a	(cM)^b
1	D1Mit411	33220299–33220410	12.6	1.6	1.6
	D1Mit303	62907596–62907723	34.8	7.4	9.1 ^#
	D1Mit286	128551097–128551241	67.0	3.4	3.9
	D1Mit102	147249520–147249632	79.0	5.3	5.6
	D1Mit36	169211172–169211344	92.3	3.9	5.6
	D1Mit149	172699229–172699330	94.2	3.9	5.7
3	D3Mit272	33007369–33007465	15.5	3	3.4
	D3Mit100	97081705–97081845	46.0	1.3	1.5
5	D5Mit122	150116320–150116477	85.0	0	0
6	D6Mit123	N/D	29.0	0.1	0.5
	D6Mit128	83471199–83471322	35.0	0.2	0.1
	D6Mit6	85277319–85277417	35.3	0.4	0.3
7	D7Mit176	63211190–63211340	27.0	0.3	0.1
9	D9Mit90	32500455–32500594	9.0	0.8	0.9
	D9Mit248	58362559–58362688	31.0	0	0
	D9Mit207	60573431–60573577	33.0	0.8	0.4
11	D11Mit4	68609257–68609504	37.0	0.2	0.9
12	D12Mit19	N/D	58.0	1.3	1.1
17	D17Mit177	48558951–48559063	24.0	1.8	1.1

^aMegabases (mouse genome database); ^bCentiMorgans (mouse genome database); ^clikelihood ratio statistic; ^dsurvival time (days); N/D: not determined.
Critical LRS statistic values established by Random Permutation Test for the trait.
(i) Mortality: significant ≥ 8.8; highly significant ≥ 15.5; suggestive ≥ 2.7.
(ii) Survival time: ^#significant ≥ 7.9; highly significant ≥ 14.3; suggestive ≥ 2.8.