Alleviation of Antioxidant Defense System by Ozonized Olive Oil in DNBS-Induced Colitis in Rats

Table 2

Macro and microscopic damage scores for the animal groups.

Treatment	Noninflamed (intrarectal vehicle)			Inflamed (intrarectal DNBS 15 mg per rat)
	Nontreated	OO (6 mg/kg)	OZO (6 mg/kg)	Nontreated	OO (6 mg/kg)	OZO (3 mg/kg)	OZO (6 mg/kg)
Macroscopic score	1.20 ± 0.12	1.11 ± 0.22	1.13 ± 0.16	7.5 ± 0.41^a	7.4 ± 0.35	5.56 ± 0.15^b	3.52 ± 0.22^b
Microscopic score	0.42 ± 0.13	0.38 ± 0.25	0.41 ± 0.28	4.52 ± 0.21^a	4.31 ± 0.42	3.20 ± 0.27^b	3.00 ± 0.24^c

< 0.001 versus intrarectal vehicle and < 0.05 and 0.01 versus inflamed non-treated group respectively.
Macroscopic assessment criteria: presence of adhesions (0–2), faecal material consistency (0–2), bowel thickness (mm), presence and extension of hyperaemia (0–6).
Microscopic assessment criteria: degree of mucosal architecture loss (0–3), cellular infiltration (0–3), muscle thickening (0–3), presence of crypt abscess and goblet cell depletion (0-1).