Involvement of Proteasome and Macrophages M2 in the Protection Afforded by Telmisartan against the Acute Myocardial Infarction in Zucker Diabetic Fatty Rats with Metabolic Syndrome

Table 2

Cardiac parameters evaluated by echocardiography in ZDF rats before and after acute myocardial infarct.

Variable	Before I/R			After 2 h reperfusion
	Vehicle	Tel 7	Tel 12	Vehicle	Tel 7	Tel 12
Morphometric
LV mass (g)	0.9±0.09	0.8±0.07	0.78±0.06	0.8±0.05	0.9±0.05	0.88±0.04
RWT	0.4±0.05	0.35±0.06	0.32±0.04	0.5±0.04	0.4±0.03	0.39±0.04
Systolic function
LVFS (%)	48±1.3	50±1.5	51±1.4	40±1.7	49±2^∗	52±1.9^∗∗
LVEF (%)	53±3	62±3.1^∗	65±2.9^∗∗	38±2.2	56±2.7^∗∗	60±2.5^∗∗
VCF (circ/sec)	0.006±0.0002	0.0057±0.0001	0.0056±0.0003	0.004±0.0003	0.007±0.0003	0.008±0.0004
Diastolic function
IVRT (ms)	28±2	29±3	29.7±4	39±1	30±0.9	28±0.7
E/A ratio (ms)	2.2±0.07	2.5±0.07^∗∗	2.6±0.06	1.4±0.1	1.9±0.04^∗∗	2.1±0.03^∗∗
Global index
MPI	0.7±0.01	0.8±0.02^∗∗	0.82±0.04^∗∗	0.40±0.02	0.6±0.01^∗∗	0.65±0.03^∗∗

Tel 7 = telmisartan (7 mg/kg); Tel 12 = telmisartan (12 mg/kg); LV = left ventricular mass and relative wall thickness (RWT); EF = ejection fraction; FS = fractional shortening and velocity of circumferential fiber shortening (VCF); IVRT = absolute left ventricular isovolumetric relaxation time; E/A ratio = ratio of maximal early diastolic peak velocity/late peak velocity of mitral flow. MPI = myocardial performance index; ms = milliseconds. ^∗𝑃<0.05 and ^∗∗𝑃<0.01 versus vehicle.