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Figure 3: The anti-inflammatory mechanism of omentin. Omentin activates AMPK, which further blocks E-selection and reduces endothelial inflammation. AMPK also activates eNOS, which has vasodilation effect and blocks JNK signaling. JNK activates inflammation through TNFα mediated COX2 effect. Moreover, omentin inhibits NF-κB signaling pathway and thus inhibits inflammation. Under obese state, the production of omentin is lower which is associated with worse proinflammation and possible lung injury.