978678.fig.002a
(a)
978678.fig.002b
(b)
Figure 2: (a) Rolling leukocytes along collecting venules (V1; >50 μm vessel diameter). (b) Rolling leukocytes along postcapillary venules (V3; <50 μm vessel diameter). Control group (CON); endotoxemia group LPS (5 mg/kg); LPS + HU308 (2.5 mg/kg), a CB2 receptor agonist; LPS + AM630 (2.5 mg/kg), a CB2 receptor antagonist/inverse agonist; LPS + URB597 (0.6 mg/kg), a FAAH inhibitor; and LPS + JZL184 (16 mg/kg), a MAGL inhibitor. In every animal six V1 venules and six V3 venules were analyzed ( –5 mice/group). Data presented as mean ± standard deviation. versus control.