IL-10 Counteracts Proinflammatory Mediator Evoked Oxidative Stress in Caco-2 Cells

Figure 2

Effect of 5-HT, adenosine, melatonin, TNFα, and/or IL-10 on CAT (a), SOD (b), and GPx (c) activity. Caco-2 cells were treated throughout the course of one day with 5-HT 100 μM, adenosine (Ado) 100 μM, melatonin (Mel) 5 mM, TNFα 5 ng/mL, or IL-10 at two concentrations, 0.01 or 25 ng/mL. Results were expressed as percentages of the enzyme activity of control cells (100%) and were indicated as the mean±SE of five independent experiments. ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001, compared with control (C); ^#𝑃<0.05, and ^###𝑃<0.001 compared with the corresponding condition of treatment without IL-10.

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