Effects of ω-3 PUFAs Supplementation on Myocardial Function and Oxidative Stress Markers in Typical Rett Syndrome

Table 2

Correlation matrix for OS markers and myocardial function variables in RTT patients following 𝜔-3 PUFAs supplementation.

Echocardiographic; variables	Plasma; NPBI	Intraerythrocyte; NPBI	Plasma; F2-IsoPs	Plasma; F4-NeuroPs	Plasma; 4-HNE PAs
MAPSE	−0.0363 (0.7654)	0.0707 (0.5608)	−0.313 (0.0117)	−0.902 (0.5466)	−0.175 (0.2552)
TAPSE	−0.0045 (0.9710)	−0.0809 (0.5121)	−0.194 (0.1238)	−0.176 (0.2374)	−0.0614 (0.6959)
𝑆^′lat	−0.215^§ (0.0764)	−0.155 (0.2045)	−0.258 (0.0392)	−0.273^§ (0.0601)	−0.394 (0.0108)
𝑆^′sept	−0.0884 (0.4840)	−0.0366 (0.7722)	−0.222 (0.0907)	−0.340 (0.0240)	−0.0433 (0.7963)
𝑆^′RV	0.211 (0.1087)	0.126 (0.3434)	0.0292 (0.8338)	−0.0485 (0.7663)	0.0941 (0.5907)
PASP	−0.133 (0.3086)	−0.212 (0.1007)	−0.218 (0.1073)	−0.0481 (0.7712)	0.069 (0.6984)

Data are Spearman’s rho correlation coefficients with in brackets 𝑃 values (𝑁=33). Bold characters indicate statistically significant correlations. §indicates statistically non-significant trend. Legend: NPBI: non protein-bound iron; F₂-IsoPs: free F₂-isoprostanes; F₄-NeuroPs: free F₄-neuroprostanes; 4-HNE PAs: 4-hydroxynonenal protein adducts; MAPSE: mitral annular plane systolic excursion; TAPSE: tricuspid annular plane systolic excursion; 𝑆^′_lat: peak systolic velocity of lateral mitral annulus; 𝑆^′_sept: peak systolic velocity of septal mitral annulus; 𝑆^′_RV: peak systolic velocity of tricuspid annulus of right ventricle; PASP: pulmonary arterial systolic pressure.