MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives

Figure 5

Inflammation in the circulation elicits in vivo leukocyte and platelet aggregation giving rise to circulating microaggregates with ensuing impairment of microcirculation, tissue ischemia, and ultimately development of ulcers on toes and fingers which may terminate with gangrene. Treatment with aspirin momentarily resolves microaggregation with improvement in microcirculation.