Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase

Figure 2

MMP-2 null mice are less susceptible to NMDA-induced RGC death. (a) Quantification of the number of Brn3a⁺ RGCs in two independent experiments (20 mM or 4.0 mM NMDA), during which different severities of RGC death were evoked, revealed that RGC death is attenuated in MMP-2 null mice (mean ± SEM, , Student’s -test). (b) RGC survival was assessed at 24 hpi by means of Brn3a immunolabeling of viable RGCs. Scale bar, 100 μm.

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