Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase

Table 1

Quantification of RGC survival in wild type and MMP-2 null (MMP-2^−/−) mice, after intravitreal injection of NMDA (1 dpi). RGC densities (RGCs/mm²) per retina are depicted. , number of animals.

	Experiment I				Experiment II
	Naive		20 mM NMDA		Naive		4.0 mM NMDA
	Wild type	MMP-2^−/−	Wild type	MMP-2^−/−	Wild type	MMP-2^−/−	Wild type	MMP-2^−/−
	3243	2960	1428	3110	3267	3228	3019	2931
	3761	3773	1207	2723	3471	3225	3038	3009
	3087	3465	1759	2955	2990	3294	2806	3418
	3428	3687	2830	2836	3465	3354	2759	2927
	3455	3417	2004	3141	3439	3557	2379	2827
		2843	2576		3646	3416	2787	3458
							3046	3276
							2990	3033
Mean	3380	3781	1967	2953	3380	3346	2853	3110
SEM	144	461	259	79	92	51	79	85
	5	6	6	5	6	6	8	8