Mediators of Inflammation / 2015 / Article / Tab 2 / Research Article
Correlation Network Analysis Reveals Relationships between MicroRNAs, Transcription Factor T-bet , and Deregulated Cytokine/Chemokine-Receptor Network in Pulmonary Sarcoidosis Table 2 Comparison of miRNA expression profiles between sarcoidosis (S) patients, subdivided according to the outcome after 2-year follow-up (Reg: regression; Prog: progression), and control subjects (C). All the data are presented as Mean Expression Level (95% confidence interval). Results are expressed relative to levels of endogenous U6 miRNA.
: number of patients. Bold font indicates significant
value.
S Reg S Prog S C ( = 48) ( = 28) ( = 20) ( = 14) (Kruskal-Wallis) S versus C Reg versus Prog miR-let-7c-5p 0.058 (0.051–0.066) 0.051 (0.042–0.060) 0.069 (0.056–0.082) 0.069 (0.052–0.087) 0.127 0.239 0.039 miR-let-7d-5p 0.136 (0.118–0.154) 0.124 (0.100–0.147) 0.153 (0.126–0.181) 0.155 (0.120–0.190) 0.250 0.256 0.103 miR-21-5p 2.022 (1.618–2.427) 1.676 (1.300–2.051) 2.508 (1.693–3.323) 2.023 (1.253–2.794) 0.585 0.833 0.161 miR-24-3p 0.522 (0.462–0.582) 0.488 (0.409–0.567) 0.570 (0.473–0.667) 0.571 (0.432–0.711) 0.432 0.405 0.174 miR-25-3p 0.110 (0.071–0.150) 0.117 (0.050–0.184) 0.101 (0.077–0.124) 0.089 (0.042–0.137) 0.485 0.434 0.191 miR-92a-3p 0.364 (0.312–0.416) 0.319 (0.255–0.384) 0.421 (0.336–0.506) 0.362 (0.272–0.452) 0.277 0.814 0.061 miR-125a-5p 0.044 (0.034–0.054) 0.046 (0.029–0.062) 0.042 (0.031–0.052) 0.058 (0.020–0.096) 0.982 0.814 0.770 miR-126-3p 0.054 (0.005–0.102) 0.077 (0.007–0.160) 0.021 (0.012–0.030) 0.057 (0.004–0.118) 0.992 0.860 0.810 miR-133a-3p 0.012 (0.010–0.015) 0.012 (0.008–0.015) 0.013 (0.009–0.017) 0.014 (0.010–0.018) 0.589 0.248 0.557 miR-146a-5p 0.304 (0.266–0.342) 0.294 (0.235–0.352) 0.319 (0.271–0.366) 0.196 (0.135–0.257) 0.020 0.006 0.331 miR-148a-3p 0.061 (0.050–0.072) 0.056 (0.042–0.069) 0.068 (0.049–0.087) 0.074 (0.050–0.097) 0.507 0.342 0.268 miR-150-5p 0.280 (0.219–0.340) 0.277 (0.199–0.355) 0.283 (0.179–0.386) 0.093 (0.061–0.125) <0.001 <0.001 0.983 miR-155-5p 0.200 (0.170–0.231) 0.169 (0.138–0.200) 0.244 (0.187–0.300) 0.168 (0.126–0.210) 0.111 0.550 0.017 miR-181a-5p 0.106 (0.091–0.121) 0.102 (0.084–0.120) 0.112 (0.085–0.139) 0.122 (0.091–0.153) 0.650 0.263 0.630 miR-199a-5p 0.012 (0.010–0.014) 0.011 (0.008–0.014) 0.013 (0.009–0.016) 0.016 (0.007–0.024) 0.919 0.748 0.532 miR-202-3p 0.009 (0.008–0.011) 0.010 (0.007–0.013) 0.013 (0.006–0.020) 0.014 (0.009–0.019) 0.173 0.036 0.564 miR-204-5p 0.008 (0.006–0.010) 0.006 (0.005–0.007) 0.010 (0.005–0.015) 0.011 (0.007–0.015) 0.030 0.031 0.061 miR-206 0.026 (0.002–0.064) 0.039 (0.003–0.101) 0.010 (0.001–0.021) 0.005 (0.003–0.007) 0.999 0.928 0.963 miR-212-3p 0.010 (0.008–0.013) 0.010 (0.008–0.012) 0.011 (0.006–0.017) 0.012 (0.009–0.016) 0.490 0.158 0.705 miR-214-3p 0.009 (0.006–0.011) 0.008 (0.006–0.010) 0.010 (0.005–0.014) 0.010 (0.005–0.014) 0.968 0.866 0.621 miR-222-3p 0.038 (0.029–0.048) 0.059 (0.047–0.072) 0.065 (0.050–0.080) 0.062 (0.052–0.071) 0.059 0.012 0.668 miR-223-3p 0.808 (0.679–0.936) 0.815 (0.615–1.014) 0.798 (0.644–0.951) 0.901 (0.695–1.106) 0.692 0.270 0.826 miR-302c-3p 0.061 (0.048–0.074) 0.060 (0.041–0.079) 0.065 (0.046–0.083) 0.089 (0.034–0.143) 0.820 0.427 0.631 miR-424-5p 0.103 (0.002–0.289) 0.013 (0.002–0.025) 0.009 (0.006–0.012) 0.018 (0.005–0.031) 0.426 0.143 0.905 miR-503-5p 0.038 (0.030–0.046) 0.041 (0.030–0.052) 0.035 (0.023–0.046) 0.058 (0.022–0.094) 0.480 0.643 0.112