Table 2: Comparison of miRNA expression profiles between sarcoidosis (S) patients, subdivided according to the outcome after 2-year follow-up (Reg: regression; Prog: progression), and control subjects (C). All the data are presented as Mean Expression Level (95% confidence interval). Results are expressed relative to levels of endogenous U6 miRNA. : number of patients. Bold font indicates significant value.

SReg SProg SC
( = 48)( = 28)( = 20)( = 14)(Kruskal-Wallis)S versus CReg versus Prog

miR-let-7c-5p0.058
(0.051–0.066)
0.051
(0.042–0.060)
0.069
(0.056–0.082)
0.069
(0.052–0.087)
0.1270.2390.039

miR-let-7d-5p0.136
(0.118–0.154)
0.124
(0.100–0.147)
0.153
(0.126–0.181)
0.155
(0.120–0.190)
0.2500.2560.103

miR-21-5p2.022
(1.618–2.427)
1.676
(1.300–2.051)
2.508
(1.693–3.323)
2.023
(1.253–2.794)
0.5850.8330.161

miR-24-3p0.522
(0.462–0.582)
0.488
(0.409–0.567)
0.570
(0.473–0.667)
0.571
(0.432–0.711)
0.4320.4050.174

miR-25-3p0.110
(0.071–0.150)
0.117
(0.050–0.184)
0.101
(0.077–0.124)
0.089
(0.042–0.137)
0.4850.4340.191

miR-92a-3p0.364
(0.312–0.416)
0.319
(0.255–0.384)
0.421
(0.336–0.506)
0.362
(0.272–0.452)
0.2770.8140.061

miR-125a-5p0.044
(0.034–0.054)
0.046
(0.029–0.062)
0.042
(0.031–0.052)
0.058
(0.020–0.096)
0.9820.8140.770

miR-126-3p0.054
(0.005–0.102)
0.077
(0.007–0.160)
0.021
(0.012–0.030)
0.057
(0.004–0.118)
0.9920.8600.810

miR-133a-3p0.012
(0.010–0.015)
0.012
(0.008–0.015)
0.013
(0.009–0.017)
0.014
(0.010–0.018)
0.5890.2480.557

miR-146a-5p0.304
(0.266–0.342)
0.294
(0.235–0.352)
0.319
(0.271–0.366)
0.196
(0.135–0.257)
0.0200.0060.331

miR-148a-3p0.061
(0.050–0.072)
0.056
(0.042–0.069)
0.068
(0.049–0.087)
0.074
(0.050–0.097)
0.5070.3420.268

miR-150-5p0.280
(0.219–0.340)
0.277
(0.199–0.355)
0.283
(0.179–0.386)
0.093
(0.061–0.125)
<0.001<0.0010.983

miR-155-5p0.200
(0.170–0.231)
0.169
(0.138–0.200)
0.244
(0.187–0.300)
0.168
(0.126–0.210)
0.1110.5500.017

miR-181a-5p0.106
(0.091–0.121)
0.102
(0.084–0.120)
0.112
(0.085–0.139)
0.122
(0.091–0.153)
0.6500.2630.630

miR-199a-5p0.012
(0.010–0.014)
0.011
(0.008–0.014)
0.013
(0.009–0.016)
0.016
(0.007–0.024)
0.9190.7480.532

miR-202-3p0.009
(0.008–0.011)
0.010
(0.007–0.013)
0.013
(0.006–0.020)
0.014
(0.009–0.019)
0.1730.0360.564

miR-204-5p0.008
(0.006–0.010)
0.006
(0.005–0.007)
0.010
(0.005–0.015)
0.011
(0.007–0.015)
0.0300.0310.061

miR-2060.026
(0.002–0.064)
0.039
(0.003–0.101)
0.010
(0.001–0.021)
0.005
(0.003–0.007)
0.9990.9280.963

miR-212-3p0.010
(0.008–0.013)
0.010
(0.008–0.012)
0.011
(0.006–0.017)
0.012
(0.009–0.016)
0.4900.1580.705

miR-214-3p0.009
(0.006–0.011)
0.008
(0.006–0.010)
0.010
(0.005–0.014)
0.010
(0.005–0.014)
0.9680.8660.621

miR-222-3p0.038
(0.029–0.048)
0.059
(0.047–0.072)
0.065
(0.050–0.080)
0.062
(0.052–0.071)
0.0590.0120.668

miR-223-3p0.808
(0.679–0.936)
0.815
(0.615–1.014)
0.798
(0.644–0.951)
0.901
(0.695–1.106)
0.6920.2700.826

miR-302c-3p0.061
(0.048–0.074)
0.060
(0.041–0.079)
0.065
(0.046–0.083)
0.089
(0.034–0.143)
0.8200.4270.631

miR-424-5p0.103
(0.002–0.289)
0.013
(0.002–0.025)
0.009
(0.006–0.012)
0.018
(0.005–0.031)
0.4260.1430.905

miR-503-5p0.038
(0.030–0.046)
0.041
(0.030–0.052)
0.035
(0.023–0.046)
0.058
(0.022–0.094)
0.4800.6430.112