Interplay between Intravitreal RvD1 and Local Endogenous Sirtuin-1 in the Protection from Endotoxin-Induced Uveitis in Rats

Figure 2

Local expression of SIRT1 following intravitreal resolvin D1 (RvD1). (a) SIRT1 expression evaluated by western blotting in the eyes of vehicle, LPS-treated rats, and LPS + RvD1 (10–100–1000 ng/kg) treated rats. (b) SIRT1 expression after EX-527, inhibitor of sirtuin-1 activity, and Boc2, FPR2/ALX receptor antagonist, in LPS and LPS + RvD1 (1000 ng/kg) rats. Results are expressed as densitometric units and represent the mean ± S.E.M. of 6 observations for each group. Significant differences with the LPS group are shown as and , while differences versus LPS + RvD1 1000 ng/kg groups are shown as .

(a)

(b)