Interplay between Intravitreal RvD1 and Local Endogenous Sirtuin-1 in the Protection from Endotoxin-Induced Uveitis in Rats

Figure 4

Representative immunohistochemistries of ocular tissues showing p53 in LPS rats alone; LPS + RvD1 (1000 ng/kg); EX-527 + LPS + RvD1 (1000 ng/kg); Boc2 + LPS + RvD1 (1000 ng/kg). RvD1 decreased p53 expression, as shown by the percentage of stained area per total area analyzed. The addition of EX-527 and Boc2 increases the expression of p53 with respect to LPS alone, while they decrease the expression of this factor if administered prior to LPS + RvD1 (1000 ng/kg). Values are mean ± S.E.M. of observations for each group. and versus LPS-treated group, while differences versus LPS + RvD1 1000 ng/kg groups are shown as . CB = ciliary body; R = retina; S = sclera; EX = Ex527; Boc = Boc2; RvD1 = resolvin D1.