iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants

Figure 2

Increased leukocyte accumulation in implants from iNOS^−/− mice. The contents of neutrophils (a) and macrophages (b) recruited to the implant were determined by myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) activities, respectively. Representative photomicrographs of H&E-stained histological sections (c). The sponges were collected at day 14 after implantation. Values were represented as means (± SEM) from groups of 8 animals each. versus WT group (Student’s -test). Bar 50 μm. Asterisks indicate the synthetic matrix. White arrows indicate blood vessels.

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