MiR-146b Mediates Endotoxin Tolerance in Human Phagocytes

Figure 6

MiR-146 a/b effect on induction of endotoxin tolerance. During overt inflammation activation of the TLR4 signaling pathway triggers the induction of proinflammatory cytokines, including TNFα, IL-6, CCL3, and IL-12. In the late phase of the inflammatory response, the induction of anti-inflammatory genes, including IL-10 and TGFβ, drives the expression of miR-146b through STAT3 and RUNX3, which negatively modulate TLR pathway at different steps, thus inducing tolerance.