Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

Figure 1

Morphological features of mitotic catastrophe. Human K562 chronic myeloid leukaemia cells during normal interphase (a) and a giant multinucleated cell following mitotic catastrophe induced by microtubule disruption (b). Interphase cell with two centrosomes (c) and normal chromosome segregation during anaphase (d). A cell containing >2 centrosomes (e) forms multipolar mitotic spindles (f) leading to aneuploidy as a result of mitotic catastrophe failure. DNA (blue), -tubulin (red) (a, b, d, f), and centrosome (red pericentrin staining) (c and e).

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