Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

Table 1

Exploiting mitotic catastrophe in cancer therapy.

Mechanism of action	Inducer	References
Microtubule targeting agents
Microtubule polymerisers	Taxanes	[34]
Microtubule depolymerisers	Vinca alkaloids
Non-microtubule antimitotic agents
Mitotic spindle targets	Aurora kinase inhibitors; Alisertib	[35, 36]
	KSP inhibitors; Eg5; AZD4877; Ispinesib; ARRY-520	[37–42]
	CENP-E inhibitors; GSK923295	[43, 44]
	PLK-1 inhibitors; B12536	[45–47]
Mitotic checkpoint targets	MPS1 inhibitors; NMS-P715; MPS1-IN-3	[48–51]
Mitotic exit inhibition	APC inhibitor; TAME	[52–54]
Centrosome disruption	Griseofulvin	[55–57]
G2 checkpoint abrogation	Chk1 inhibitors; UCN-01; AZD7762	[58–63]
	HDAC inhibition; Trichostatin A	[64–66]