Protection from Endotoxic Uveitis by Intravitreal Resolvin D1: Involvement of Lymphocytes, miRNAs, Ubiquitin-Proteasome, and M1/M2 Macrophages

Figure 8

Western Blotting showing that Resolvin D1 (RvD1) treatment reduces the ocular proteasome system. Ocular tissue homogenates from the eyes of LPS-treated rats showed highest levels of 20S and 26S proteasome subunits. Intravitreal RvD1 (10-100-1000 ng/kg) post-LPS decreased the levels of the proteasome subunits with the respect to LPS alone. Results are expressed as densitometric units and represented the mean ± SEM of observation for each group. Vh = vehicle; and versus LPS.