Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction

Figure 2

TSA inhibited LPS-induced anhedonia. Mice were pretreated with saline (Controls) or TSA (0.3 mg/kg) for 1 h and then intraperitoneally challenged with saline or E. coli LPS (1 mg/kg). The sucrose preference was determined 35 to 47 h after LPS injection. Bars represent the mean ± SEM (). compared with the Control group; ^# compared with the LPS-only group.