Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction

Figure 3

TSA attenuated LPS-induced HDAC2 and HDAC5 expression in the hippocampus and cortex of mice. Mice were pretreated with saline (Controls) or TSA (0.3 mg/kg) for 1 h and then intraperitoneally challenged with saline or E. coli LPS (1 mg/kg) ( in each group). (a) HDAC2 and HDAC5 mRNA were detected using RT-PCR. The right panel shows the quantification of mRNA expression from six independent experiments. compared with the Control group; ^# compared with the LPS-only group. (b) Immunohistochemical staining showed that HDAC2 and HDAC5 expression were increased in the cortex of mice after being LPS challenged, which were reduced in LPS + TSA mice.

(a)

(b)