Authors Manuscript title Year Human Animals Tissue HMGB1 level in Laboratory tests Functional or imaging tests
Shang et al. [14 ]. “Serum High Mobility Group Box Protein 1 as a Clinical Marker for Non-Small-Cell Lung Cancer” 2009 x — Serum > — Spirometry
Ferhani et al. [15 ]. “Expression of High-Mobility Group Box 2010 x — BAL > TNF-α , TNF-RII, IL1-β , IL1-RA, RAGE Spirometry
Hou et al. [16 ]. “High Mobility Group Protein B1 (HMGB1) in Asthma: Comparison of Patients with Chronic Obstructive Pulmonary Disease and Healthy Controls” 2011 x — Sputum > — Spirometry
Bezerra et al. [17 ] “Long-Term Exposure to Cigarette Smoke Impairs Lung Function and Increases HMGB-1 Expression in Mice” 2011 x BAL > SOD, CAT, GPx, MMP-2,9,12 —
Kanazawa et al. [18 ] “Validity of HMGB1 Measurement in Epithelial Lining Fluid in Patients with COPD”
2012 x — Central BAL = IL-8, PMN elastase TC
Wang et al. [19 ] “Effect of NF‐κ B Inhibitor on High‐ Mobility Group Protein B1 Expression in a COPD Rat Model”
2013 — x Lung T. > NF- —
Ko et al. [20 ] “High Expression of High-Mobility Group Box
2014 x — Plasma > — Spirometry
Zhang et al. [21 ] “Changes of HMGB1 and sRAGE during the Recovery of COPD Exacerbation” 2014 x — Plasma > Fibrinogen, hsCRP, RAGE Spirometry
Zabini et al. [22 ] “High-Mobility Group Box-
2015 x — Lung T. > TLR4, RAGE —
Di Stefano et al. [23 ] “Innate Immunity but Not NLRP3 Inflammasome Activation Correlates with Severity of Stable COPD” 2014 x — BAL = IL-27, IL-37, NRLP7 —
Iwamoto et al. [24 ] “Soluble Receptor for Advanced Glycation End-Products and Progression of Airway Disease” 2014 X — Plasma = sRAGE —
Heijink et al. [25 ] “Cigarette Smoke-Induced Damage-Associated Molecular Pattern Release from Necrotic Neutrophils Triggers Proinflammatory Mediator Release” 2015 x x BAL — — —
Pouwels et al. [8 ] “Increased Serum Levels of LL37, HMGB1 and S100A9 during Exacerbation in COPD Patients” 2015 x — Serum > Galectin-3, S100A9, sRAGE, LL37, dsDNA —
