Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-κB Nuclear Translocation and Suppression of Experimental Asthma in Mice

Figure 7

Effect of DMPF-1 on bronchial hyperresponsiveness to methacholine. Female BALB/c mice were sensitized and challenged with OVA 1 hour after treatment with various doses of DMPF-1. After 24 hours of the last OVA challenge, the mice were exposed to (a) increasing doses of methacholine (6.25, 12.5, 25, and 50 mg/mL) in an enclosed chamber for 3 min and the readings were taken for 5 min after each nebulization. (b) The Penh of all groups at the highest dose of methacholine. The values are expressed as mean ± SEM (). , significantly different from the OVA-challenged group.

(a)

(b)