Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-κB Nuclear Translocation and Suppression of Experimental Asthma in Mice

Figure 9

Representative hematoxylin and eosin- (H&E-) stained lung sections. Airways and blood vessels of (a) naïve mice, (b) OVA-challenged mice, (c) dexamethasone-treated mice, (d) 100 mg/kg DMPF-1-treated mice, (e) 20 mg/kg DMPF-1-treated mice, (f) 2 mg/kg DMPF-1-treated mice, and (g) 0.2 mg/kg DMPF-1-treated mice. These photos were taken under 40x objective (400x magnification) using light microscope (Bar = 50 μm). This experiment used 10 mice per group (). (h) For quantitative analysis of infiltration of inflammatory cells, the numbers of total inflammatory cells per airway and blood vessel were obtained by adding the average number of cells from perivascular count/number of airways and peribronchial count/number of blood vessels. The values are expressed as mean ± SEM (). , significantly different from the OVA-challenged group.

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