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Mediators of Inflammation
Volume 2015, Article ID 181986, 7 pages
Research Article

TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis

1Institute of Immunology, Faculty of Medicine, Comenius University, 81372 Bratislava, Slovakia
2Medirex Ltd., 82016 Bratislava, Slovakia
3Department of Pneumology and Phthisiology, Faculty of Medicine, Comenius University, 82101 Bratislava, Slovakia
41st Department of Otorhinolaryngology, Faculty of Medicine, Comenius University, 85107 Bratislava, Slovakia

Received 31 December 2014; Revised 8 May 2015; Accepted 18 May 2015

Academic Editor: Kaijun Niu

Copyright © 2015 Maria Bucova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


TREM-1 and TREM-2 molecules are members of the TREM transmembrane glycoproteins. In our previous study we identified increased expressions of TREM-1 and TREM-2 receptors in pulmonary sarcoidosis (PS). Only a few studies concerning the association between vitamin D and TREM receptor expression can be found. The aim of our current study was to determine the association between the levels of an inactive form of 25(OH)D vitamin and TREM-1 and TREM-2 receptor expressions. We have detected low levels of 25(OH)D vitamin in 79% of PS patients. Only 21% of patients had normal serum level of 25(OH)D vitamin with values clustered within the low-normal range. The most striking findings were the increased TREM-2 expressions on myeloid cells surfaces in BALF of PS patients with normal 25(OH)D vitamin serum levels compared with those with its decreased levels. The total number of TREM-2 positive cells was 5.7 times higher and the percentage of TREM-2 positive cells was also significantly increased in BALF of PS patients with normal compared to PS patients with low 25(OH)D vitamin serum levels. A significant correlation between total TREM-2 expression and vitamin D levels has been detected too. However, we have not detected similar differences in TREM-1expression and 25(OH)D vitamin serum levels.