Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2015, Article ID 181986, 7 pages
http://dx.doi.org/10.1155/2015/181986
Research Article

TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis

1Institute of Immunology, Faculty of Medicine, Comenius University, 81372 Bratislava, Slovakia
2Medirex Ltd., 82016 Bratislava, Slovakia
3Department of Pneumology and Phthisiology, Faculty of Medicine, Comenius University, 82101 Bratislava, Slovakia
41st Department of Otorhinolaryngology, Faculty of Medicine, Comenius University, 85107 Bratislava, Slovakia

Received 31 December 2014; Revised 8 May 2015; Accepted 18 May 2015

Academic Editor: Kaijun Niu

Copyright © 2015 Maria Bucova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. M. Du Bois, N. Goh, D. McGrath, and P. Cullinan, “Is there a role for microorganisms in the pathogenesis of sarcoidosis?” Journal of Internal Medicine, vol. 253, no. 1, pp. 4–17, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. L. S. Newman, C. S. Rose, and L. A. Maier, “Sarcoidosis,” The New England Journal of Medicine, vol. 336, no. 17, pp. 1224–1234, 1997. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Adorini and G. Penna, “Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists,” Human Immunology, vol. 70, no. 5, pp. 345–352, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Hewison, L. Freeman, S. V. Hughes et al., “Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells,” The Journal of Immunology, vol. 170, no. 11, pp. 5382–5390, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Hewison, “Vitamin D and the immune system: new perspectives on an old theme,” Endocrinology and Metabolism Clinics of North America, vol. 39, no. 2, pp. 365–379, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Fabri, S. Stenger, D.-M. Shin et al., “Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages,” Science translational medicine, vol. 3, no. 104, 2011. View at Google Scholar · View at Scopus
  7. B. P. Barna, D. A. Culver, A. Kanchwala et al., “Alveolar macrophage cathelicidin deficiency in severe sarcoidosis,” Journal of Innate Immunity, vol. 4, no. 5-6, pp. 569–578, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. P. T. Liu, S. Stenger, H. Li et al., “Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response,” Science, vol. 311, no. 5768, pp. 1770–1773, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. R. P. Baughman, J. Janovcik, M. Ray, N. Sweiss, and E. E. Lower, “Calcium and vitamin D metabolism in sarcoidosis,” Sarcoidosis Vasculitis and Diffuse Lung Diseases, vol. 30, no. 2, pp. 113–120, 2013. View at Google Scholar · View at Scopus
  10. N. J. Sweiss, E. E. Lower, P. Korsten, T. B. Niewold, M. J. Favus, and R. P. Baughman, “Bone health issues in sarcoidosis,” Current Rheumatology Reports, vol. 13, no. 3, pp. 265–272, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. O. P. Sharma, “Sarcoidosis associated with vitamin D deficiency,” Child Care Today, vol. 5, no. 10, pp. 18–22, 2012. View at Google Scholar
  12. L. Richeldi, M. Mariani, M. Losi et al., “Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections,” European Respiratory Journal, vol. 24, no. 2, pp. 247–250, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. R. M. Determann, J. L. Millo, S. Gibot et al., “Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia,” Intensive Care Medicine, vol. 31, no. 11, pp. 1495–1500, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. C.-L. Liu, W.-Y. Hsieh, C.-L. Wu, H.-T. Kuo, and Y.-T. Lu, “Triggering receptor expressed on myeloid cells-1 in pleural effusions: a marker of inflammatory disease,” Respiratory Medicine, vol. 101, no. 5, pp. 903–909, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Ferat-Osorio, N. Esquivel-Callejas, I. Wong-Baeza et al., “The increased expression of TREM-1 on monocytes is associated with infectious and non-infectious inflammatory processes,” Journal of Surgical Research, vol. 150, no. 1, pp. 110–117, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Bucova, M. Suchankova, M. Dzurilla et al., “Inflammatory marker sTREM-1 reflects the clinical stage and respiratory tract obstruction in allergic asthma bronchiale patients and correlates with number of neutrophils,” Mediators of Inflammation, vol. 2012, Article ID 628754, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. J. A. Hamerman, J. R. Jarjoura, M. B. Humphrey, M. C. Nakamura, W. E. Seaman, and L. L. Lanier, “Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12,” Journal of Immunology, vol. 177, no. 4, pp. 2051–2055, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Suchankova, M. Bucova, E. Tibenska et al., “Triggering receptor expressed on myeloid cells-1 and 2 in bronchoalveolar lavage fluid in pulmonary sarcoidosis,” Respirology, vol. 18, no. 3, pp. 455–462, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Suchankova, M. Bucova, E. Tibenska et al., “STREM-1 in bronchoalveolar lavage fluid in patients with pulmonary sarcoidosis, effect of smoking and inflammation,” Bratislava Medical Journal, vol. 114, no. 12, pp. 702–707, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. I. Rigo, L. McMahon, P. Dhawan et al., “Induction of triggering receptor expressed on myeloid cells (TREM-1) in airway epithelial cells by 1,25(OH)2 vitamin D3,” Innate Immunity, vol. 18, no. 2, pp. 250–257, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Zhang, D. Y. M. Leung, B. N. Richers et al., “Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1,” The Journal of Immunology, vol. 188, no. 5, pp. 2127–2135, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. American Thoracic Society/European Respiratory Society, The World Association of Sarcoidosis, and Other Granulomatous Disorders (WASOG), “Statement on sarcoidosis,” American Journal of Respiratory Critical Care Medicine, vol. 160, pp. 736–755, 1999. View at Google Scholar
  23. A. Bouchon, J. Dietrich, and M. Colonna, “Cutting edge: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes,” The Journal of Immunology, vol. 164, no. 10, pp. 4991–4995, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Paradowska-Gorycka and M. Jurkowska, “Structure, expression pattern and biological activity of molecular complex TREM-2/DAP12,” Human Immunology, vol. 74, no. 6, pp. 730–737, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. O. Sharif and S. Knapp, “From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infection,” Immunobiology, vol. 213, no. 9-10, pp. 701–713, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. I. R. Turnbull, S. Gilfillan, M. Cella et al., “Cutting edge: TREM-2 attenuates macrophage activation,” Journal of Immunology, vol. 177, no. 6, pp. 3520–3524, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. C. J. Pelham and D. K. Agrawal, “Emerging roles for triggering receptor expressed on myeloid cells receptor family signaling in inflammatory diseases,” Expert Review of Clinical Immunology, vol. 10, no. 2, pp. 243–256, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Hiasa, M. Abe, A. Nakano et al., “GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-α converting enzyme (TACE),” Blood, vol. 114, no. 20, pp. 4517–4526, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. J. W. Ford and D. W. McVicar, “TREM and TREM-like receptors in inflammation and disease,” Current Opinion in Immunology, vol. 21, no. 1, pp. 38–46, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. L. Helming, E. Tomasello, T. R. Kyriakides et al., “Essential role of DAP12 signaling in macrophage programming into a fusion-competent state,” Science Signaling, vol. 1, no. 43, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. E.-N. N'Diaye, C. S. Branda, S. S. Branda et al., “TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria,” Journal of Cell Biology, vol. 184, no. 2, pp. 215–223, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Gawish, R. Martins, B. Böhm et al., “Triggering receptor expressed on myeloid cells-2 fine-tunes inflammatory responses in murine Gram-negative sepsis,” The FASEB Journal, vol. 29, no. 4, pp. 1247–1257, 2015. View at Publisher · View at Google Scholar
  33. Q. Chen, K. Zhang, Y. Jin et al., “Triggering receptor expressed on myeloid cells-2 protects against polymicrobial sepsis by enhancing bacterial clearance,” American Journal of Respiratory and Critical Care Medicine, vol. 188, no. 2, pp. 201–212, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Takahashi, C. D. P. Rochford, and H. Neumann, “Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2,” The Journal of Experimental Medicine, vol. 201, no. 4, pp. 647–657, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. O. P. Sharma, “Vitamin D, calcium, and sarcoidosis,” Chest, vol. 109, no. 2, pp. 535–539, 1996. View at Publisher · View at Google Scholar · View at Scopus
  36. C. Thota, T. Farmer, R. E. Garfield, R. Menon, and A. Al-Hendy, “Vitamin D elicits anti-inflammatory response, inhibits contractile-associated proteins, and modulates Toll-like receptors in human myometrial cells,” Reproductive Sciences, vol. 20, no. 4, pp. 463–475, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. T.-H. Kim, B. Lee, E. Kwon et al., “Regulation of TREM-1 expression by 1,25-dihydroxyvitamin D3 in human monocytes/macrophages,” Immunology Letters, vol. 154, no. 1-2, pp. 80–85, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. B. Lee, E. Kwon, Y. Kim et al., “1α,25-Dihydroxyvitamin D3 upregulates HIF-1 and TREM-1 via mTOR signaling,” Immunology Letters, vol. 163, no. 1, pp. 14–21, 2015. View at Publisher · View at Google Scholar