Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes

Figure 4

Effect of cGAS overexpression on TNFα-induced inflammatory responses in RA FLS. (a) FLS infected with cGAS-vector produced significantly higher amounts of IL-1β, IL-6, MMP-1, and MMP-3 than did FLS infected with control () when exposed to TNFα stimulation for 30 min. (b) Overexpression of cGAS significantly increased TNFα-mediated ERK1/2 and AKT phosphorylation by Western blotting.

(a)

(b)