Interleukin-1 as a Common Denominator from Autoinflammatory to Autoimmune Disorders: Premises, Perils, and Perspectives

Table 3

Recent and ongoing clinical trials on interleukin-1 blockade in the monogenic autoinflammatory disorders.

	Phase	Status	Study	Disease	ClinicalTrials.gov identifier
Anakinra	3	Recruiting	Kineret (anakinra) in adult patients with colchicine-resistant familial Mediterranean fever	FMF	NCT01705756
	1	Completed	The use of Kineret (anakinra) in the treatment of familial cold autoinflammatory syndrome	FACS	NCT00214851
Canakinumab	3	Recruiting	Efficacy, safety, and tolerability of ACZ885 in pediatric patients with the following cryopyrin-associated periodic syndromes: familial cold autoinflammatory syndrome, Muckle-Wells syndrome, and CINCA syndrome	CAPS	NCT01576367
	3	Completed	The safety and efficacy of canakinumab in patients aged 4 years or older diagnosed with cryopyrin-associated periodic syndromes in Canada	CAPS	NCT01105507
	3	Completed	Efficacy and safety study of canakinumab administered for 6 months (24 weeks) in Japanese patients with cryopyrin-associated periodic syndromes followed by an extension phase	CAPS	NCT00991146
	2	Completed	Evaluation of the safety and efficacy of canakinumab in pediatric patients with colchicine-intolerant or colchicine-resistant familial Mediterranean fever	FMF	NCT01148797
	2	Completed	Efficacy and safety of canakinumab in patients with colchicine-resistant familial Mediterranean fever	FMF	NCT01088880
	3	Active, not recruiting	Efficacy, safety, and tolerability of ACZ885 in pediatric patients with the following cryopyrin-associated periodic syndromes: familial cold autoinflammatory syndrome, Muckle-Wells syndrome, and CINCA syndrome	CAPS	NCT01302860
	—	Recruiting	Clinical outcomes and safety: a registry study of Ilaris (canakinumab) patients (B-confident)	CAPS	NCT01213641
	2	Active, not recruiting	Canakinumab in patients with active hyper-IgD syndrome	MKD	NCT01303380
	2	Completed	Efficacy and safety study of ACZ885 in patients with active recurrent or chronic tumor necrosis factor receptor-associated periodic syndrome	TRAPS	NCT01242813
	3	Recruiting	Efficacy and safety of canakinumab in patients with hereditary periodic fevers	HPFs	NCT02059291

CAPS: cryopyrin-associated periodic syndromes; FACS: familial cold autoinflammatory syndrome; FMF: familial Mediterranean fever; HPFs: hereditary periodic fever syndromes; MKD: mevalonate kinase deficiency syndrome; TRAPS: tumor necrosis factor receptor-associated periodic syndrome.