Increased Migratory and Activation Cell Markers of Peripheral Blood Lymphocytes in an Experimental Model of Nephrotic Syndrome

Figure 4

Schematic figure of proposed pathogenesis of kidney damage in doxorubicin-induced nephropathy. Doxorubicin induced chemical kidney damage, which activated tissue macrophages and increased local oxidative stress. This situation caused organ impairment and biochemical alterations. Activated macrophages released cytokines and chemokines, which activated and recruited new cells, especially monocytes and lymphocytes from lymph nodes. These cells accumulated in the kidneys, inducing collagen accumulation and, consequently, worsened kidney damage.