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Mediators of Inflammation
Volume 2015, Article ID 215761, 9 pages
Research Article

Expression and Function of Hypoxia Inducible Factor-1α and Vascular Endothelial Growth Factor in Pulp Tissue of Teeth under Orthodontic Movement

1Department of Orthodontics, School of Stomatology, Shandong University, Jinan, Shandong, China
2Shandong Provincial Key Laboratory of Oral Tissue Regeneration, No. 44, Wen Hua Xi Lu, Shandong, Jinan 250012, China
3Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100050, China

Received 9 May 2015; Revised 7 July 2015; Accepted 2 August 2015

Academic Editor: Sandra Helena Penha Oliveira

Copyright © 2015 Fulan Wei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Orthodontic force may lead to cell damage, circulatory disturbances, and vascular changes of the dental pulp, which make a hypoxic environment in pulp. In order to maintain the homeostasis of dental pulp, hypoxia will inevitably induce the defensive reaction. However, this is a complex process and is regulated by numerous factors. In this study, we established an experimental animal model of orthodontic tooth movement to investigate the effects of mechanical force on the expression of VEGF and HIF-1α in dental pulp. Histological analysis of dental pulp and expressions of HIF-1α and VEGF proteins in dental pulp were examined. The results showed that inflammation and vascular changes happened in dental pulp tissue in different periods. Additionally, there were significant changes in the expression of HIF-1α and VEGF proteins under orthodontic force. After application of mechanical load, expression of HIF-1α and VEGF was markedly positive in 1, 3, 7 d, and 2 w groups, and then it weakened in 4 w group. These findings suggested that the expression of HIF-1α and VEGF was enhanced by mechanical force. HIF-1α and VEGF may play an important role in retaining the homeostasis of dental pulp during orthodontic tooth movement.