Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2015, Article ID 215761, 9 pages
http://dx.doi.org/10.1155/2015/215761
Research Article

Expression and Function of Hypoxia Inducible Factor-1α and Vascular Endothelial Growth Factor in Pulp Tissue of Teeth under Orthodontic Movement

1Department of Orthodontics, School of Stomatology, Shandong University, Jinan, Shandong, China
2Shandong Provincial Key Laboratory of Oral Tissue Regeneration, No. 44, Wen Hua Xi Lu, Shandong, Jinan 250012, China
3Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100050, China

Received 9 May 2015; Revised 7 July 2015; Accepted 2 August 2015

Academic Editor: Sandra Helena Penha Oliveira

Copyright © 2015 Fulan Wei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Matsuda, N. Morita, K. Matsuda, and M. Watanabe, “Proliferation and differentiation of human osteoblastic cells associated with differential activation of MAP kinases in response to epidermal growth factor, hypoxia, and mechanical stress in vitro,” Biochemical and Biophysical Research Communications, vol. 249, no. 2, pp. 350–354, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. B. A. Ramazanzadeh, A. A. Sahhafian, N. Mohtasham, N. Hassanzadeh, A. Jahanbin, and M. T. Shakeri, “Histological changes in human dental pulp following application of intrusive and extrusive orthodontic forces,” Journal of oral science, vol. 51, no. 1, pp. 109–115, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. M. von Böhl, Y. Ren, P. S. Fudalej, and A. M. Kuijpers-Jagtman, “Pulpal reactions to orthodontic force application in humans: a systematic review,” Journal of Endodontics, vol. 38, no. 11, pp. 1463–1469, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Sano, M. Ikawa, J. Sugawara, H. Horiuchi, and H. Mitani, “The effect of continuous intrusive force on human pulpal blood flow,” European Journal of Orthodontics, vol. 24, no. 2, pp. 159–166, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Santamaria Jr., D. Milagres, A. S. Stuani, M. B. S. Stuani, and A. C. De Oliveira Ruellas, “Initial changes in pulpal microvasculature during orthodontic tooth movement: a stereological study,” European Journal of Orthodontics, vol. 28, no. 3, pp. 217–220, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. K. M. Galler, A. Yasue, A. C. Cavender, P. Bialek, G. Karsenty, and R. N. D'Souza, “A novel role for twist-1 in pulp homeostasis,” Journal of Dental Research, vol. 86, no. 10, pp. 951–955, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Shigehara, K. Matsuzaka, and T. Inoue, “Morphohistological change and expression of HSP70, osteopontin and osteocalcin mRNAs in rat dental pulp cells with orthodontic tooth movement,” The Bulletin of Tokyo Dental College, vol. 47, no. 3, pp. 117–124, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Folkman and Y. Shing, “Angiogenesis,” Journal of Biological Chemistry, vol. 267, no. 16, pp. 10931–10934, 1992. View at Google Scholar · View at Scopus
  9. A. Loboda, A. Jozkowicz, and J. Dulak, “HIF-1 and HIF-2 transcription factors—similar but not identical,” Molecules and Cells, vol. 29, no. 5, pp. 435–442, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Ivan, K. Kondo, H. Yang et al., “HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing,” Science, vol. 292, no. 5516, pp. 464–468, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. D. R. Mole, P. H. Maxwell, C. W. Pugh, and P. J. Ratcliffe, “Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing,” IUBMB Life, vol. 52, no. 1-2, pp. 43–47, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Yamakawa, L. X. Liu, T. Date et al., “Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors,” Circulation Research, vol. 93, no. 7, pp. 664–673, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Dai and A. B. M. Rabie, “VEGF: an essential mediator of both angiogenesis and endochondral ossification,” Journal of Dental Research, vol. 86, no. 10, pp. 937–950, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. I.-W. Song, W.-R. Li, L.-Y. Chen et al., “Palmitoyl acyltransferase, Zdhhc13, Facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model,” PLoS ONE, vol. 9, no. 3, Article ID e92194, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Maes, P. Carmeliet, K. Moermans et al., “Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188,” Mechanisms of Development, vol. 111, no. 1-2, pp. 61–73, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Ferrara, “Role of vascular endothelial growth factor in regulation of physiological angiogenesis,” The American Journal of Physiology—Cell Physiology, vol. 280, no. 6, pp. C1358–C1366, 2001. View at Google Scholar · View at Scopus
  17. F. L. Wei, J. Geng, H. Wang, B. J. Zhang, and F. Zhang, “Expression of HIF-1α and VEGF in human dental pulp cells under mechanical stretch,” Shanghai Kou Qiang Yi Xue, vol. 21, no. 5, pp. 501–505, 2012. View at Google Scholar
  18. T. J. Franzen, P. Brudvik, and V. Vandevska-Radunovic, “Periodontal tissue reaction during orthodontic relapse in rat molars,” European Journal of Orthodontics, vol. 35, no. 2, pp. 152–159, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Hou, Y. Chen, X. Meng et al., “Compressive force regulates ephrinB2 and EphB4 in osteoblasts and osteoclasts contributing to alveolar bone resorption during experimental tooth movement,” Korean Journal of Orthodontics, vol. 44, no. 6, pp. 320–329, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. F. A. L. Sabuncuoglu and S. Ersahan, “Changes in maxillary molar pulp blood flow during orthodontic intrusion,” Australian Orthodontic Journal, vol. 30, no. 2, pp. 152–160, 2014. View at Google Scholar · View at Scopus
  21. Y. Konno, T. Daimaruya, M. Iikubo et al., “Morphologic and hemodynamic analysis of dental pulp in dogs after molar intrusion with the skeletal anchorage system,” American Journal of Orthodontics and Dentofacial Orthopedics, vol. 132, no. 2, pp. 199–207, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Tripuwabhrut, P. Brudvik, I. Fristad, and S. Rethnam, “Experimental orthodontic tooth movement and extensive root resorption: periodontal and pulpal changes,” European Journal of Oral Sciences, vol. 118, no. 6, pp. 596–603, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. D. N. Lazzaretti, G. S. Bortoluzzi, L. F. Torres Fernandes, R. Rodriguez, R. A. Grehs, and M. S. Martins Hartmann, “Histologic evaluation of human pulp tissue after orthodontic intrusion,” Journal of Endodontics, vol. 40, no. 10, pp. 1537–1540, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Van Uden, N. S. Kenneth, and S. Rocha, “Regulation of hypoxia-inducible factor-1α by NF-κB,” Biochemical Journal, vol. 412, no. 3, pp. 477–484, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. H. S. Chae, H.-J. Park, H. R. Hwang et al., “The effect of antioxidants on the production of pro-inflammatory cytokines and orthodontic tooth movement,” Molecules and Cells, vol. 32, no. 2, pp. 189–196, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Yamaguchi, T. Kojima, M. Kanekawa, N. Aihara, A. Nogimura, and K. Kasai, “Neuropeptides stimulate production of interleukin-1β, interleukin-6, and tumor necrosis factor-α in human dental pulp cells,” Inflammation Research, vol. 53, no. 5, pp. 199–204, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. H. K. Eltzschig and P. Carmeliet, “Hypoxia and inflammation,” The New England Journal of Medicine, vol. 364, no. 7, pp. 656–665, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. P. Römer, M. Wolf, J. Fanghänel, C. Reicheneder, and P. Proff, “Cellular response to orthodontically-induced short-term hypoxia in dental pulp cells,” Cell and Tissue Research, vol. 355, no. 1, pp. 173–180, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. C. T. Taylor and E. P. Cummins, “The role of NF-κB in hypoxia-induced gene expression,” Annals of the New York Academy of Sciences, vol. 1177, pp. 178–184, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Bonello, C. Zähringer, R. S. BelAiba et al., “Reactive oxygen species activate the HIF-1α promoter via a functional NFκB site,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 4, pp. 755–761, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Cao, “Angiogenesis modulates adipogenesis and obesity,” The Journal of Clinical Investigation, vol. 117, no. 9, pp. 2362–2368, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. R. F. Gariano and T. W. Gardner, “Retinal angiogenesis in development and disease,” Nature, vol. 438, no. 7070, pp. 960–966, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. N. Akeno, J. Robins, M. Zhang, M. F. Czyzyk-Krzeska, and T. L. Clemens, “Induction of vascular endothelial growth factor by IGF-I in osteoblast-like cells is mediated by the PI3K signaling pathway through the hypoxia-inducible factor-2α,” Endocrinology, vol. 143, no. 2, pp. 420–425, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. H. Motohira, J. Hayashi, J. Tatsumi, M. Tajima, H. Sakagami, and K. Shin, “Hypoxia and reoxygenation augment bone-resorbing factor production from human periodontal ligament cells,” Journal of Periodontology, vol. 78, no. 9, pp. 1803–1809, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. D. Chen, W. Tian, Y. Li, W. Tang, and C. Zhang, “Osteoblast-specific transcription factor Osterix (Osx) and HIF-1α cooperatively regulate gene expression of vascular endothelial growth factor (VEGF),” Biochemical and Biophysical Research Communications, vol. 424, no. 1, pp. 176–181, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. G. L. Semenza, “HIF-1: mediator of physiological and pathophysiological responses to hypoxia,” Journal of Applied Physiology, vol. 88, no. 4, pp. 1474–1480, 2000. View at Google Scholar · View at Scopus
  37. C. Wan, S. R. Gilbert, Y. Wang et al., “Activation of the hypoxia-inducible factor-1α pathway accelerates bone regeneration,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 2, pp. 686–691, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. T. R. Arnett, D. C. Gibbons, J. C. Utting et al., “Hypoxia is a major stimulator of osteoclast formation and bone resorption,” Journal of Cellular Physiology, vol. 196, no. 1, pp. 2–8, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. H. J. Knowles and N. A. Athanasou, “Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis,” Journal of Pathology, vol. 218, no. 2, pp. 256–264, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. P. Gerwins, E. Sköldenberg, and L. Claesson-Welsh, “Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis,” Critical Reviews in Oncology/Hematology, vol. 34, no. 3, pp. 185–194, 2000. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Neelam, M. M. Brooks, and P. R. Cammarata, “Lenticular cytoprotection. Part 1: the role of hypoxia inducible factors-1α and -2α and vascular endothelial growth factor in lens epithelial cell survival in hypoxia,” Molecular Vision, vol. 19, pp. 1–15, 2013. View at Google Scholar · View at Scopus
  42. Y. Wang, C. Wan, L. Deng et al., “The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development,” Journal of Clinical Investigation, vol. 117, no. 6, pp. 1616–1626, 2007. View at Publisher · View at Google Scholar · View at Scopus