Transcriptional Regulators of Claudins in Epithelial Tight Junctions

Table 1

Regulators of claudins.

TJ proteins	Regulator	Promoter binding region	Expression/reference
Claudin-1	Sp-1	−138 to −76 bp	↑ [16]
	cdx-2	−1160 to −850 bp	↑ [17]
Claudin-2	cdx-2	−1067 to −1 bp	↑ [18]
Claudin-3	Sp-1	−112 to −74 bp	↑ [19]
Claudin-4	Sp-1	−105 to −49 bps	↑ [20]
Claudin-5	FoxO1	−2,906 to −2,871 bps	↓ [21]
Claudin-7	ELF-3	−150 bps	↑ [22]
Claudin-15	Hnf4α	−693 to −47 bps	↑ [23]
Claudin-19	Sp-1	−139 to −75 bps	↑ [24]

Note: arrow (↑) = upregulation, arrow (↓) = downregulation.