Review Article
Transcriptional Regulators of Claudins in Epithelial Tight Junctions
Table 1
Regulators of claudins.
| TJ proteins | Regulator | Promoter binding region | Expression/reference |
| Claudin-1 | Sp-1 | −138 to −76 bp | ↑ [16] | cdx-2 | −1160 to −850 bp | ↑ [17] | Claudin-2 | cdx-2 | −1067 to −1 bp | ↑ [18] | Claudin-3 | Sp-1 | −112 to −74 bp | ↑ [19] | Claudin-4 | Sp-1 | −105 to −49 bps | ↑ [20] | Claudin-5 | FoxO1 | −2,906 to −2,871 bps | ↓ [21] | Claudin-7 | ELF-3 | −150 bps | ↑ [22] | Claudin-15 | Hnf4α | −693 to −47 bps | ↑ [23] | Claudin-19 | Sp-1 | −139 to −75 bps | ↑ [24] |
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Note: arrow (↑) = upregulation, arrow (↓) = downregulation.
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