Systemic Inflammatory Markers Are Closely Associated with Atherogenic Lipoprotein Subfractions in Patients Undergoing Coronary Angiography
Table 1
Baseline characteristics.
Characteristics
All subjects ()
CAD ()
Non-CAD ()
value
Coronary risk factors
Age (years)
56.6 ± 10.0
57.9 ± 9.7
54.0 ± 10.2
<0.001
Male, % ()
64.4 (335)
71.8 (252)
28.2 (99)
<0.001
BMI (kg/m2)
25.7 ± 3.5
25.9 ± 3.4
25.4 ± 3.5
0.147
Smoking, % ()
43.5 (226)
50.1 (176)
29.6 (50)
<0.001
Hypertension, % ()
60.0 (312)
67.0 (235)
45.6 (77)
<0.001
Diabetes mellitus, % ()
21.7 (113)
25.1 (88)
14.8 (25)
0.009
Dyslipidemia, % ()
67.7 (352)
70.7 (248)
61.5 (104)
0.045
Family history of CAD, % ()
16.0 (83)
17.9 (63)
11.8 (20)
0.096
Lipoprotein parameters
VLDL cholesterol (mg/dL)
44.0 ± 12.3
44.0 ± 10.8
43.9 ± 14.9
0.253
IDL cholesterol (mg/dL)
48.7 ± 13.8
48.3 ± 13.4
49.4 ± 14.6
0.606
LDL cholesterol (mg/dL)
126.1 ± 38.7
125.7 ± 38.4
127.0 ± 39.3
0.723
Large LDL cholesterol
28.7 ± 10.1
28.3 ± 10.1
29.4 ± 10.1
0.277
Intermediate LDL cholesterol
20.5 ± 9.5
20.7 ± 9.5
20.1 ± 9.4
0.466
Small LDL cholesterol
8.6 ± 9.6
9.0 ± 9.8
7.9 ± 9.3
0.092
LDL score (%)
0.13 ± 0.13
0.14 ± 0.13
0.12 ± 0.13
0.067
Mean LDL particle size ()
266.7 ± 6.0
266.4 ± 5.9
267.2 ± 6.0
0.079
HDL cholesterol (mg/dL)
43.3 ± 13.9
42.5 ± 14.2
45.1 ± 13.1
0.054
Large HDL cholesterol
14.0 ± 7.4
13.5 ± 7.2
15.1 ± 7.7
0.027
Intermediate HDL cholesterol
20.9 ± 6.5
20.7 ± 7.0
21.2 ± 5.3
0.360
Small HDL cholesterol
8.6 ± 3.3
8.5 ± 3.4
8.8 ± 3.1
0.318
Inflammatory markers
WBC count (×109/L)
6.1 ± 1.7
6.2 ± 1.8
5.9 ± 1.4
0.076
Neutrophil count (×109/L)
3.7 ± 1.4
3.8 ± 1.4
3.5 ± 1.1
0.019
Lymphocyte count (×109/L)
1.9 ± 0.6
1.9 ± 0.6
2.0 ± 0.5
0.260
Monocyte count (×109/L)
0.39 ± 0.29
0.40 ± 0.34
0.37 ± 0.12
0.147
hs-CRP (mg/L)
2.6 ± 9.8
2.8 ± 3.1
2.2 ± 2.8
<0.001
Fibrinogen (g/L)
3.1 ± 0.8
3.2 ± 0.8
3.0 ± 0.6
0.001
ESR (mm/h)
9.8 ± 9.7
10.1 ± 10.2
9.1 ± 8.6
0.463
D-dimer (g/mL)
0.37 ± 0.44
0.40 ± 0.37
0.33 ± 0.56
0.115
Data are expressed as % (), median (IQR), or mean ± SD. BMI: body mass index; CAD: coronary artery disease; VLDL: very low-density lipoprotein; IDL: intermediate-density lipoprotein; LDL: low-density lipoprotein; HDL: high-density lipoprotein; WBC: white blood cell; hs-CRP: high sensitivity C-reactive protein; ESR: erythrocyte sedimentation rate.
