Systemic Inflammatory Markers Are Closely Associated with Atherogenic Lipoprotein Subfractions in Patients Undergoing Coronary Angiography
Table 3
Relationship of LDL and HDL subfractions with multimarker inflammatory index.
Multimarker inflammatory index
Q1 ()
Q2 ()
Q3 ()
Q4 ()
for trend
LDL subfractions
Large LDL cholesterol (mg/dL)
Model 1
30.07 ± 0.89
27.92 ± 0.89
28.44 ± 0.89
28.03 ± 0.89
0.289
Model 2
30.36 ± 0.89
27.84 ± 0.89
28.30 ± 0.89
27.96 ± 0.89
0.157
Model 3
30.01 ± 0.91
27.89 ± 0.89
28.53 ± 0.91
28.06 ± 0.90
0.338
Intermediate LDL cholesterol (mg/dL)
Model 1
18.02 ± 0.83
20.76 ± 0.83
21.19 ± 0.83
22.02 ± 0.83
0.005
Model 2
18.03 ± 0.84
20.62 ± 0.83
21.29 ± 0.84
22.06 ± 0.83
0.005
Model 3
18.06 ± 0.85
20.72 ± 0.83
21.23 ± 0.85
22.01 ± 0.83
0.009
Small LDL cholesterol (mg/dL)
Model 1
5.87 ± 0.87
8.92 ± 0.87
9.46 ± 0.87
10.89 ± 0.87
0.001
Model 2
5.73 ± 0.87
8.72 ± 0.87
9.69 ± 0.87
11.00 ± 0.87
<0.001
Model 3
5.79 ± 0.90
8.74 ± 0.87
9.64 ± 0.89
10.98 ± 0.87
0.001
LDL score (%)
Model 1
0.09 ± 0.01
0.14 ± 0.01
0.15 ± 0.01
0.16 ± 0.01
<0.001
Model 2
0.09 ± 0.01
0.13 ± 0.01
0.15 ± 0.01
0.16 ± 0.01
<0.001
Model 3
0.10 ± 0.01
0.13 ± 0.01
0.15 ± 0.01
0.16 ± 0.01
0.001
Mean LDL particle size ()
Model 1
268.42 ± 0.52
266.38 ± 0.52
266.21 ± 0.52
265.51 ± 0.52
0.001
Model 2
268.54 ± 0.53
266.44 ± 0.52
266.09 ± 0.53
265.45 ± 0.52
<0.001
Model 3
268.39 ± 0.54
266.45 ± 0.52
266.18 ± 0.53
265.49 ± 0.52
0.001
HDL subfractions
Large HDL cholesterol (mg/dL)
Model 1
15.29 ± 0.64
13.57 ± 0.64
14.03 ± 0.64
13.02 ± 0.64
0.080
Model 2
15.97 ± 0.61
13.75 ± 0.61
13.44 ± 0.61
12.73 ± 0.61
0.002
Model 3
15.33 ± 0.60
13.62 ± 0.59
13.95 ± 0.60
13.04 ± 0.59
0.049
Intermediate HDL cholesterol (mg/dL)
Model 1
21.69 ± 0.57
20.70 ± 0.57
20.27 ± 0.57
20.65 ± 0.57
0.329
Model 2
22.07 ± 0.56
20.71 ± 0.56
20.02 ± 0.56
20.52 ± 0.56
0.066
Model 3
21.96 ± 0.57
20.68 ± 0.56
20.08 ± 0.57
20.58 ± 0.56
0.129
Small HDL cholesterol (mg/dL)
Model 1
8.52 ± 0.29
8.84 ± 0.29
8.49 ± 0.29
8.40 ± 0.30
0.740
Model 2
8.56 ± 0.30
8.79 ± 0.29
8.50 ± 0.30
8.40 ± 0.29
0.815
Model 3
8.63 ± 0.30
8.80 ± 0.29
8.42 ± 0.30
8.37 ± 0.29
0.729
Values were obtained from general linear models. Model 1 was unadjusted. Model 2 was adjusted for age and sex. Model 3 was additionally adjusted for BMI, hypertension, diabetes, smoking, and incidence of CAD. BMI: body mass index; CAD: coronary artery disease; LDL: low-density lipoprotein; HDL: high-density lipoprotein.
