Interleukin-18 Increases TLR4 and Mannose Receptor Expression and Modulates Cytokine Production in Human Monocytes

Figure 1

TLR2, TLR4 and MR expression in CD14⁺ monocytes. CD14⁺ monocytes (column (a)) were treated with IL-18 (100 ng/mL) (column (b)), or IL-18 (100 ng/mL) plus anti-IL-18 (0,5 μg/mL) (column (c)), for 18 hours and evaluated by flow cytometry. Box-and-whisker plot showing data distribution of 15 healthy subjects tested for TLR2 (d), TLR4 (e), and MR (f). Horizontal lines represent the median values; boxes represent the 25th to 75th percentiles and vertical lines the 10th to 90th percentiles. Statistical significance between groups is indicated (  × other groups).