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Mediators of Inflammation
Volume 2015, Article ID 236839, 9 pages
http://dx.doi.org/10.1155/2015/236839
Research Article

Interleukin-18 Increases TLR4 and Mannose Receptor Expression and Modulates Cytokine Production in Human Monocytes

1Departamento de Patologia, Faculdade de Medicina, Universidade Estadual Paulista (UNESP), Campus Botucatu, 18618-970 Botucatu, SP, Brazil
2Departamento de Microbiologia e Imunologia, Instituto de Biociências, Universidade Estadual Paulista (UNESP), Campus Botucatu, 18618-970 Botucatu, SP, Brazil
3Faculdade de Medicina, Universidade Estadual Paulista (UNESP), Campus Botucatu, Hemocentro, 18618-970 Botucatu, SP, Brazil

Received 6 June 2014; Revised 2 September 2014; Accepted 3 September 2014

Academic Editor: Fábio Santos Lira

Copyright © 2015 Luciane Alarcão Dias-Melicio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. A. Gracie, S. E. Robertson, and I. B. McInnes, “Interleukin-18,” Journal of Leukocyte Biology, vol. 73, no. 2, pp. 213–224, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. C. A. Dinarello, “Interleukin-18 and the pathogenesis of inflammatory diseases,” Seminars in Nephrology, vol. 27, no. 1, pp. 98–114, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Iannello, S. Samaranil, O. Debbeche et al., “Role of interleukin-18 in the development and pathogenesis of AIDS,” AIDS Reviews, vol. 11, no. 3, pp. 115–125, 2009. View at Google Scholar · View at Scopus
  4. D. E. Smith, “The biological paths of IL-1 family members IL-18 and IL-33,” Journal of Leukocyte Biology, vol. 89, no. 3, pp. 383–392, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Ghayur, S. Banerjee, M. Hugunin et al., “Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production,” Nature, vol. 386, no. 6625, pp. 619–623, 1997. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Gu, K. Kuida, H. Tsutsui et al., “Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme,” Science, vol. 275, no. 5297, pp. 206–209, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. J.-C. Sirard, C. Vignal, R. Dessein, and M. Chamaillard, “Nod-like receptors: cytosolic watchdogs for immunity against pathogens,” PLoS Pathogens, vol. 3, no. 12, article e152, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. M. H. Shaw, T. Reimer, Y.-G. Kim, and G. Nuñez, “NOD-like receptors (NLRs): bona fide intracellular microbial sensors,” Current Opinion in Immunology, vol. 20, no. 4, pp. 377–382, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Chen, M. H. Shaw, Y.-G. Kim, and G. Nuñez, “NOD-like receptors: role in innate immunity and inflammatory disease,” Annual Review of Pathology: Mechanisms of Disease, vol. 4, pp. 365–398, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. R. C. Coll and L. A. J. O'Neill, “New insights into the regulation of signalling by toll-like receptors and nod-like receptors,” Journal of Innate Immunity, vol. 2, no. 5, pp. 406–421, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. T.-D. Kanneganti, “Central roles of NLRs and inflammasomes in viral infection,” Nature Reviews Immunology, vol. 10, no. 10, pp. 688–698, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. B. K. Davis, H. Wen, and J. P.-Y. Ting, “The Inflammasome NLRs in immunity, inflammation, and associated diseases,” Annual Review of Immunology, vol. 29, pp. 707–735, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Okamura, S.-I. Kashiwamura, H. Tsutsui, T. Yoshimoto, and K. Nakanishi, “Regulation of interferon-γ production by IL-12 and IL-18,” Current Opinion in Immunology, vol. 10, no. 3, pp. 259–264, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. J. T. Chang, B. M. Segal, K. Nakanishi, H. Okamura, and E. M. Shevach, “The costimulatory effect of IL-18 on the induction of antigen-specific IFN-γ production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor β2 subunit,” European Journal of Immunology, vol. 30, no. 4, pp. 1113–1119, 2000. View at Google Scholar · View at Scopus
  15. K. Nakanishi, T. Yoshimoto, H. Tsutsui, and H. Okamura, “Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu,” Cytokine and Growth Factor Reviews, vol. 12, no. 1, pp. 53–72, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Torigoe, S. Ushio, T. Okura et al., “Purification and characterization of the human interleukin-18 receptor,” Journal of Biological Chemistry, vol. 272, no. 41, pp. 25737–25742, 1997. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Coma, R. Peña, J. Blanco et al., “Treatment of monocytes with interleukin (IL)-12 plus IL-18 stimulates survival, differentiation and the production of CXC chemokine ligands (CXCL)8, CXCL9 and CXCL10,” Clinical & Experimental Immunology, vol. 145, no. 3, pp. 535–544, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. G. M. Barton, “A calculated response: control of inflammation by the innate immune system,” The Journal of Clinical Investigation, vol. 118, no. 2, pp. 413–420, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. O. Joffre, M. A. Nolte, R. Spörri, and C. R. E. Sousa, “Inflammatory signals in dendritic cell activation and the induction of adaptive immunity,” Immunological Reviews, vol. 227, no. 1, pp. 234–247, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. M. T. M. Vega and A. de Andrés Martín, “The significance of toll-like receptors in human diseases,” Allergologia et Immunopathologia, vol. 37, no. 5, pp. 252–263, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Kawai and S. Akira, “Toll-like receptors and their crosstalk with other innate receptors in infection and immunity,” Immunity, vol. 34, no. 5, pp. 637–650, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Rakoff-Nahoum and R. Medzhitov, “Role of toll-like receptors in tissue repair and tumorigenesis,” Biochemistry, vol. 73, no. 5, pp. 555–561, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Takeda and S. Akira, “Microbial recognition by Toll-like receptors,” Journal of Dermatological Science, vol. 34, no. 2, pp. 73–82, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Fukata, A. S. Vamadevan, and M. T. Abreu, “Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders,” Seminars in Immunology, vol. 21, no. 4, pp. 242–253, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. H.-Y. Qi and J. H. Shelhamer, “Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages,” The Journal of Biological Chemistry, vol. 280, no. 47, pp. 38969–38975, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. C.-S. Yang, D.-M. Shin, H.-M. Lee et al., “ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling,” Cellular Microbiology, vol. 10, no. 3, pp. 741–754, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. C. E. McCoy and L. A. O'Neill, “The role of toll-like receptors in macrophages,” Frontiers in Bioscience, vol. 13, no. 1, pp. 62–70, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Ozato, H. Tsujimura, and T. Tamura, “Toll-like receptor signaling and regulation of cytokine gene expression in the immune system,” BioTechniques, vol. 33, no. 4, pp. S66–S72, 2002. View at Google Scholar · View at Scopus
  29. U. Gazi and L. Martinez-Pomares, “Influence of the mannose receptor in host immune responses,” Immunobiology, vol. 214, no. 7, pp. 554–561, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. K. Yong, E. M. Ooi, G. Dogra et al., “Elevated interleukin-12 and interleukin-18 in chronic kidney disease are not associated with arterial stiffness,” Cytokine, vol. 64, no. 1, pp. 39–42, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. Z. Mallat, A. Corbaz, A. Scoazec et al., “Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability,” Circulation, vol. 104, no. 14, pp. 1598–1603, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Elhage, J. Jawien, M. Rudling et al., “Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice,” Cardiovascular Research, vol. 59, no. 1, pp. 234–240, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. G. K. Hansson and A. Hermansson, “The immune system in atherosclerosis,” Nature Immunology, vol. 12, no. 3, pp. 204–212, 2011. View at Google Scholar
  34. B. A. V. Cerqueira, W. V. Boas, A. D. Zanette, M. G. Reis, and M. S. Goncalves, “Increased concentrations of IL-18 and uric acid in sickle cell anemia: contribution of hemolysis, endothelial activation and the inflammasome,” Cytokine, vol. 56, no. 2, pp. 471–476, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Blankenberg, L. Tiret, C. Bickel et al., “Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina,” Circulation, vol. 106, no. 1, pp. 24–30, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. L. C. O'Brien, E. Mezzaroma, B. W. van Tassell et al., “Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure,” Molecular Medicine, vol. 20, no. 1, pp. 221–229, 2014. View at Publisher · View at Google Scholar
  37. S. Toldo, E. Mezzaroma, L. O'Brien et al., “Interleukin-18 mediates interleukin-1-induced cardiac dysfunction,” American Journal of Physiology: Heart and Circulatory Physiology, vol. 306, no. 7, pp. H1025–H1031, 2014. View at Publisher · View at Google Scholar · View at Scopus
  38. Y. Yang, J. Qiao, R. Li, and M. Z. Li, “Is interleukin-18 associated with polycystic ovary syndrome?” Reproductive Biology and Endocrinology, vol. 9, article 7, 2011. View at Publisher · View at Google Scholar
  39. A. Ciaramella, C. Della Vedova, F. Salani et al., “Increased levels of serum IL-18 are associated with the long-term outcome of severe traumatic brain injury,” NeuroImmunoModulation, vol. 21, no. 1, pp. 8–12, 2013. View at Publisher · View at Google Scholar · View at Scopus
  40. J. Wang, X. Liu, M. Xie, J. Xie, W. Xiong, and Y. Xu, “Increased expression of interleukin-18 and its receptor in peripheral blood of patients with chronic obstructive pulmonary disease,” COPD: Journal of Chronic Obstructive Pulmonary Disease, vol. 9, no. 4, pp. 375–381, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. M. A. Chattergoon, J. S. Levine, R. Latanich, W. O. Osburn, D. L. Thomas, and A. L. Cox, “High plasma interleukin-18 levels mark the acute phase of hepatitis C virus infection,” Journal of Infectious Diseases, vol. 204, no. 11, pp. 1730–1740, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Ikeda, N. Aoki, M. Kido et al., “Progression of autoimmune hepatitis is mediated by IL-18-producing dendritic cells and hepatic CXCL9 expression in mice,” Hepatology, vol. 60, no. 1, pp. 224–236, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. F. N. Lauw, A. J. H. Simpson, J. M. Prins et al., “Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ- inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis,” Journal of Infectious Diseases, vol. 180, no. 6, pp. 1878–1885, 1999. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Yamamoto and K. Takeda, “Current views of toll-like receptor signaling pathways,” Gastroenterology Research and Practice, vol. 2010, Article ID 240365, 8 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. T. R. Radstake, M. F. Roelofs, Y. M. Jenniskens et al., “Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-γ,” Arthritis and Rheumatism, vol. 50, no. 12, pp. 3856–3865, 2004. View at Publisher · View at Google Scholar · View at Scopus
  46. C. E. Becker and L. A. J. O'Neill, “Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs,” Seminars in Immunopathology, vol. 29, no. 3, pp. 239–248, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. A. J. Puren, P. Razeghi, G. Fantuzzi, and C. A. Dinarello, “Interleukin-18 enhances lipopolysaccharide-induced interferon-γ production in human whole blood cultures,” Journal of Infectious Diseases, vol. 178, no. 6, pp. 1830–1834, 1998. View at Publisher · View at Google Scholar · View at Scopus
  48. Q. Xie, W. W. Shen, J. Zhong, C. Huang, L. Zhang, and J. Li, “Lipopolysaccharide/adenosine triphosphate induces IL-1β; and IL-18 secretion through the NLRP3 inflammasome in RAW264.7 murine macrophage cells,” International Journal of Molecular Medicine, vol. 34, no. 1, pp. 341–349, 2014. View at Publisher · View at Google Scholar
  49. E. J. McKenzie, P. R. Taylor, R. J. Stillion et al., “Mannose receptor expression and function define a new population of murine dendritic cells,” The Journal of Immunology, vol. 178, no. 8, pp. 4975–4983, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. S. Vautier, M. D. G. Sousa, and G. D. Brown, “C-type lectins, fungi and Th17 responses,” Cytokine and Growth Factor Reviews, vol. 21, no. 6, pp. 405–412, 2010. View at Publisher · View at Google Scholar · View at Scopus
  51. J. Zhang, S. D. Tachado, N. Patel et al., “Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro,” Journal of Leukocyte Biology, vol. 78, no. 3, pp. 665–674, 2005. View at Publisher · View at Google Scholar · View at Scopus
  52. S. E. M. Heinsbroek, P. R. Taylor, F. O. Martinez, L. Martinez-Pomares, G. D. Brown, and S. Gordon, “Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis,” PLoS Pathogens, vol. 4, no. 11, Article ID e1000218, 2008. View at Publisher · View at Google Scholar · View at Scopus
  53. S. K. Pathak, S. Basu, A. Bhattacharyya, M. Kundu, and J. Basu, “Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M induction negatively regulates toll-like receptor-dependent interleukin-12 p40 production in macrophages,” The Journal of Biological Chemistry, vol. 280, no. 52, pp. 42794–42800, 2005. View at Publisher · View at Google Scholar · View at Scopus
  54. M. V. S. Rajaram, M. N. Brooks, J. D. Morris, J. B. Torrelles, A. K. Azad, and L. S. Schlesinger, “Mycobacterium tuberculosis activates human macrophage peroxisome proliferator-activated receptor γ linking mannose receptor recognition to regulation of immune responses,” Journal of Immunology, vol. 185, no. 2, pp. 929–942, 2010. View at Publisher · View at Google Scholar · View at Scopus
  55. C. Jiang, A. T. Ting, and B. Seed, “PPAR-γ agonists inhibit production of monocyte inflammatory cytokines,” Nature, vol. 391, no. 6662, pp. 82–86, 1998. View at Publisher · View at Google Scholar · View at Scopus
  56. M. Ricote, J. T. Huang, J. S. Welch, and C. K. Glass, “The peroxisome proliferator-activated receptorγ (PPARγ) as a regulator of monocyte/macrophage function,” Journal of Leukocyte Biology, vol. 66, no. 5, pp. 733–739, 1999. View at Google Scholar · View at Scopus
  57. M. Ricote, A. C. Li, T. M. Willson, C. J. Kelly, and C. K. Glass, “The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation,” Nature, vol. 391, no. 6662, pp. 79–82, 1998. View at Publisher · View at Google Scholar · View at Scopus
  58. H. J. Welters, S. C. McBain, M. Tadayyon, J. H. B. Scarpello, S. A. Smith, and N. G. Morgan, “Expression and functional activity of PPARγ in pancreatic β cells,” British Journal of Pharmacology, vol. 142, no. 7, pp. 1162–1170, 2004. View at Publisher · View at Google Scholar · View at Scopus
  59. B. P. Kota, T. H.-W. Huang, and B. D. Roufogalis, “An overview on biological mechanisms of PPARs,” Pharmacological Research, vol. 51, no. 2, pp. 85–94, 2005. View at Publisher · View at Google Scholar · View at Scopus
  60. M. V. Schmidt, B. Brüne, and A. Von Knethen, “The nuclear hormone receptor PPARγ as a therapeutic target in major diseases,” TheScientificWorldJournal, vol. 10, pp. 2181–2197, 2010. View at Publisher · View at Google Scholar · View at Scopus
  61. F. A. Monsalve, R. D. Pyarasani, F. Delgado-Lopez, and R. Moore-Carrasco, “Peroxisome proliferator-activated receptor targets for the treatment of metabolic diseases,” Mediators of Inflammation, vol. 2013, Article ID 549627, 18 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  62. A. von Knethen and B. Brüne, “Activation of peroxisome proliferator-activated receptor γ by nitric oxide in monocytes/macrophages down-regulates p47phox and attenuates the respiratory burst,” The Journal of Immunology, vol. 169, no. 5, pp. 2619–2626, 2002. View at Publisher · View at Google Scholar · View at Scopus
  63. M. Zeyda, D. Farmer, J. Todoric et al., “Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production,” International Journal of Obesity, vol. 31, no. 9, pp. 1420–1428, 2007. View at Publisher · View at Google Scholar · View at Scopus
  64. J. M. Bruun, B. Stallknecht, J. W. Helge, and B. Richelsen, “Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss,” European Journal of Endocrinology, vol. 157, no. 4, pp. 465–471, 2007. View at Publisher · View at Google Scholar · View at Scopus
  65. T. W. Weiss, H. Arnesen, M. Trøseid et al., “Adipose tissue expression of interleukin-18 mRNA is elevated in subjects with metabolic syndrome and independently associated with fasting glucose,” Wiener Klinische Wochenschrift, vol. 123, no. 21-22, pp. 650–654, 2011. View at Publisher · View at Google Scholar · View at Scopus
  66. P. Jitprasertwong, K. M. Jaedicke, C. J. Nile, P. M. Preshaw, and J. J. Taylor, “Leptin enhances the secretion of interleukin (IL)-18, but not IL-1β, from human monocytes via activation of caspase-1,” Cytokine, vol. 65, no. 2, pp. 222–230, 2014. View at Publisher · View at Google Scholar · View at Scopus
  67. R. Faggioni, J. Jones-Carson, D. A. Reed et al., “Leptin-deficient (ob/ob) mice are protected from t cell-mediated hepatotoxicity: role of tumor necrosis factor α and IL-18,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 5, pp. 2367–2372, 2000. View at Publisher · View at Google Scholar · View at Scopus
  68. K. M. Jaedicke, A. Roythorne, K. Padget, S. Todryk, P. M. Preshaw, and J. J. Taylor, “Leptin up-regulates TLR2 in human monocytes,” Journal of Leukocyte Biology, vol. 93, no. 4, pp. 561–571, 2013. View at Publisher · View at Google Scholar · View at Scopus
  69. N. Esser, L. L'Homme, A. De Roover et al., “Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue,” Diabetologia, vol. 56, no. 11, pp. 2487–2497, 2013. View at Publisher · View at Google Scholar · View at Scopus
  70. K. J. Tracey and A. Cerami, “Tumor necrosis factor, other cytokines and disease,” Annual Review of Cell Biology, vol. 9, pp. 317–343, 1993. View at Publisher · View at Google Scholar · View at Scopus
  71. D. R. Rodrigues, L. A. Dias-Melicio, S. A. Calvi, M. T. S. Peraçoli, and A. M. V. C. Soares, “Paracoccidioides brasiliensis killing by IFN-γ, TNF-α and GM-CSF activated human neutrophils: role for oxygen metabolites,” Medical Mycology, vol. 45, no. 1, pp. 27–33, 2007. View at Publisher · View at Google Scholar · View at Scopus
  72. A. P. Moreira, L. A. Dias-Melicio, M. T. S. Peraçoli, S. A. Calvi, and A. M. Victoriano De Campos Soares, “Killing of Paracoccidioides brasiliensis yeast cells by IFN-γ and TNF-α activated murine peritoneal macrophages: Evidence of H2O2 and NO effector mechanisms,” Mycopathologia, vol. 166, no. 1, pp. 17–23, 2008. View at Publisher · View at Google Scholar · View at Scopus
  73. H. K. Takahashi, H. Iwagaki, R. Hamano, T. Yoshino, N. Tanaka, and M. Nishibori, “Effect of nicotine on IL-18-initiated immune response in human monocytes,” Journal of Leukocyte Biology, vol. 80, no. 6, pp. 1388–1394, 2006. View at Publisher · View at Google Scholar · View at Scopus
  74. H. K. Takahashi, H. Iwagaki, T. Yoshino et al., “Prostaglandin E2 inhibits IL-18-induced ICAM-1 and B7.2 expression through EP2/EP4 receptors in human peripheral blood mononuclear cells,” Journal of Immunology, vol. 168, no. 9, pp. 4446–4454, 2002. View at Publisher · View at Google Scholar · View at Scopus
  75. H. K. Takahashi, H. Iwagaki, R. Tamura et al., “Unique regulation profile of prostaglandin E1 on adhesion molecule expression and cytokine production in human peripheral blood mononuclear cells,” Journal of Pharmacology and Experimental Therapeutics, vol. 307, no. 3, pp. 1188–1195, 2003. View at Publisher · View at Google Scholar · View at Scopus
  76. T. R. Mosmann, “Properties and functions of interleukin-10,” Advances in Immunology, vol. 56, pp. 1–26, 1994. View at Publisher · View at Google Scholar · View at Scopus
  77. A. P. Moreira, L. A. Dias-Melicio, and A. M. V. C. Soares, “Interleukin-10 but not Transforming Growth Factor beta inhibits murine activated macrophages Paracoccidioides brasiliensis killing: effect on H2O2 and NO production,” Cellular Immunology, vol. 263, no. 2, pp. 196–203, 2010. View at Publisher · View at Google Scholar · View at Scopus
  78. M. A. Cassatella, “The neutrophil: one of the cellular targets of interleukin-10,” International Journal of Clinical and Laboratory Research, vol. 28, no. 3, pp. 148–161, 1998. View at Publisher · View at Google Scholar · View at Scopus
  79. D. L. Costa, L. A. Dias-Melicio, M. J. Acorci et al., “Effect of interleukin-10 on the Paracoccidioides brasiliensis killing by gamma-interferon activated human neutrophils,” Microbiology and Immunology, vol. 51, no. 1, pp. 73–80, 2007. View at Publisher · View at Google Scholar · View at Scopus
  80. F. O. Martinez, L. Helming, and S. Gordon, “Alternative activation of macrophages: an immunologic functional perspective,” Annual Review of Immunology, vol. 27, pp. 451–483, 2009. View at Publisher · View at Google Scholar · View at Scopus
  81. S. Recalcati, M. Locati, E. Gammella, P. Invernizzi, and G. Cairo, “Iron levels in polarized macrophages: regulation of immunity and autoimmunity,” Autoimmunity Reviews, vol. 11, no. 12, pp. 883–889, 2012. View at Publisher · View at Google Scholar · View at Scopus