Role of Polymorphisms of Inducible Nitric Oxide Synthase and Endothelial Nitric Oxide Synthase in Idiopathic Environmental Intolerances

Figure 1

Effects of different NOS2A C2087T (Ser608Leu) genotypes on nitrite/nitrate plasma levels in IEI patients (MCS = 170; SMCS = 108; FM/CFS = 89), grouped together (a) or separated (b), and controls (). Box-plots graphically depict the variation in plasma nitrite/nitrate concentrations of patients and healthy subjects, having different NOS2A C2087T genotypes, through their quartiles. The bottom and top of the boxes are the first and third quartiles, and the band inside the boxes is the second quartile (the median); lines extending vertically from the boxes (whiskers) indicate variability outside the upper and lower quartiles (the ends of the whiskers represent the minimum and maximum of all of the data). MCS, multiple chemical sensitivity; SMCS, suspected multiple chemical sensitivity; FM/CFS, fibromyalgia/chronic fatigue syndrome; controls, healthy subjects.

(a)

(b)