Research Article
Role of Polymorphisms of Inducible Nitric Oxide Synthase and Endothelial Nitric Oxide Synthase in Idiopathic Environmental Intolerances
Table 1
Allele and genotype frequencies of NOS2A and NOS3 SNPs in IEI patients and healthy subjects.
| | Genotype | MCS
() | SMCS
() | FM/CFS
() | Controls
() |
| | NOS2A C2087T (Ser608Leu) | | | | | | CC (Ser/Ser) | 60.6% | 52.8% | 65.2% | 60.2% | | CT (Ser/Leu) | 34.7% | 41.7% | 30.3% | 36.2% | | TT (Leu/Leu) | 4.7% | 5.6% | 4.5% | 3.6% | | C allele frequency | 0.78 | 0.74 | 0.80 | 0.78 | | T allele frequency | 0.22 | 0.26 | 0.20 | 0.22 | | −786T>C NOS3 | | | | | | TT | 32.9% | 34.3% | 33.7% | 33.2% | | TC | 45.9% | 46.3% | 49.4% | 44.5% | | CC | 21.2% | 19.4% | 16.9% | 22.3% | | T allele frequency | 0.56 | 0.56 | 0.58 | 0.55 | | C allele frequency | 0.44 | 0.44 | 0.42 | 0.45 |
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|
MCS, multiple chemical sensitivity; SMCS, suspected multiple chemical sensitivity; FM/CFS, fibromyalgia/chronic fatigue syndrome; controls, healthy subjects.
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