Role of Polymorphisms of Inducible Nitric Oxide Synthase and Endothelial Nitric Oxide Synthase in Idiopathic Environmental Intolerances

Table 3

Genotype and allele frequencies of the NOS2A promoter pentanucleotide microsatellite −2.5 kb (CCTTT)_n short and long repeats in IEI patients and healthy subjects.

Genotype	MCS ()	SMCS ()	FM/CFS ()	Controls ()
(CCTTT)s/(CCTTT)s	29.4%	25.0%	15.7%^*	30.1%
(CCTTT)s/(CCTTT)l	24.7%	40.7%	64.1%^***	27.0%
(CCTTT)l /(CCTTT)l	45.9%	34.3%	20.2%^***	42.9%
Allele frequency
(CCTTT)s	0.4	0.5	0.5	0.4
(CCTTT)l	0.6	0.5	0.5	0.6

MCS, multiple chemical sensitivity; SMCS: suspected multiple chemical sensitivity; FM/CFS, fibromyalgia/chronic fatigue syndrome; controls, healthy subjects. s: short repeats (CCTTT; l: long repeats (CCTTT. , significant difference in comparison with controls. , , and significant difference in comparison with FM/CFS. significant difference in comparison with SMCS.