Genetic Polymorphisms of Multidrug Resistance Gene-1 (MDR1/ABCB1) and Glutathione S-Transferase Gene and the Risk of Inflammatory Bowel Disease among Moroccan Patients

Table 1

Pooled analysis of studies exploring the role of MDR1 C3435T in IBD.

Study	Cases (event/total)	Controls (events/total)	Odds ratio	95% CI
Senhaji et al. 2015 (the current paper)	75/220	53/120	0,65	0,41 to 1,03
Yang et al. 2015 [36]	121/298	152/446	1,32	0,97 to 1,79
Bonyadi et al. 2013 [37]	120/232	99/184	0,92	0,62 to 1,35
Brinar et al. 2013 [32]	304/612	106/238	1,22	0,91 to 1,66
Dudarewicz et al. 2012 [38]	77/108	111/137	0,58	0,32 to 1,05
Huebner et al. 2009 [30]	600/759	156/195	0,94	0,63 to 1,39
Ardizzone et al. 2007 [39]	180/288	123/210	1,17	0,81 to 1,69
Fischer el al. 2007 [29]	308/414	106/146	1,09	0,71 to 1,67
Karlsen et al. 2007 [40]	231/268	310/368	1,16	0,74 to 1,82
Fiedler et al. 2007 [41]	304/388	782/1015	1,07	0,81 to 1,43
Onnie et al. 2006 [9]	1071/1408	219/280	0,88	0,65 to 1,20
Oostenbrug et al. 2006 [42]	757/1420	293/530	0,92	0,75 to 1,12
Ho et al. 2006 [43]	352/428	205/260	1,24	0,84 to 1,83
Urcelay et al. 2006 [44]	405/614	227/324	0,82	0,61 to 1,10
Palmieri et al. 2005 [45]	697/946	335/450	0,96	0,74 to 1,24
Ho et al. 2005 [46]	486/603	288/370	1,18	0,86 to 1,62
Glas et al. 2004 [47]	213/258	195/265	1,69	1,11 to 2,59
Schwab et al. 2003 [10]	216/275	201/275	1,34	0,91 to 1,99
Total (fixed effects)	6517/9539	3961/5813	1,03	0,96 to 1,12
Total (random effects)	6517/9539	3961/5813	1,04	0,94 to 1,15

Test for heterogeneity: ; DF = 17; %; .