Genetic Polymorphisms of Multidrug Resistance Gene-1 (MDR1/ABCB1) and Glutathione S-Transferase Gene and the Risk of Inflammatory Bowel Disease among Moroccan Patients

Table 3

Pooled analysis of studies exploring the role of GSTM1 and GSTT1 in IBD.

Study	Cases (event/total)	Controls (events/total)	Odds ratio	95% CI
Studies on GSTM1
Senhaji et al. 2015 (the current paper)	62/110	51/100	1,24	0,72 to 2,13
Karban et al. 2011 [21]	277/574	300/528	0,70	0,55 to 0,89
Mittal et al. 2007 [23]	61/105	49/164	3,25	1,95 to 5,42
Total (fixed effects)	400/789	400/792	0,97	0,80 to 1,18
Total (random effects)	400/789	400/792	1,39	0,55 to 3,53
Studies on GSTT1
Senhaji et al. 2015 (the current paper)	40/110	17/100	2,79	1,45 to 5,34
Karban et al. 2011 [21]	172/574	97/528	1,90	1,43 to 2,52
Mittal et al. 2007 [23]	95/105	26/164	50,42	23,23 to 109,4
Total (fixed effects)	307/789	140/792	3,13	2,49 to 3,95
Total (random effects)	307/789	140/792	6,26	1,06 to 36,87