Genetic Polymorphisms of Multidrug Resistance Gene-1 (MDR1/ABCB1) and Glutathione S-Transferase Gene and the Risk of Inflammatory Bowel Disease among Moroccan Patients

Table 4

Distribution of genotypes and alleles of MDR1 polymorphisms in IBD patients and controls.

Genotypes/alleles	Control	CD	OR	P value	UC	OR	P value
	(%)	(%)	(95% CI)		(%)	(95% CI)
1236CC	43 (43)	33 (43)	Ref.		12 (36)	Ref.
1236CT	49 (49)	42 (55)	1.1 (0.6–2)	0.75	13 (39)	1 (0.4–2.3)	1
1236TT	8 (8)	2 (3)	0.3 (0.01–0.6)	0.2	8 (24)	3.6 (1–11.5)	0.05
1236C	135 (67.5)	108 (70)	Ref.		37 (56)	Ref.
1236T	65 (32.5)	46 (30)	0.9 (0.6–0.4)	0.65	29 (44)	1.6 (1–2.9)	0.1
HWE p	0.24	0.01			0.29
3435CC	39 (39)	30 (39)	Ref.		16 (48)	Ref.
3435CT	51 (51)	40 (52)	1 (0.5–0.9)	1	13 (39)	0.6 (0.3–1.4)	0.3
3435TT	10 (10)	7 (9)	0.9 (0.3–2.7)	1	4 (12)	1 (0.3–3.6)	1
3435C	129 (64.5)	100 (65)	Ref.		45 (68)	Ref.
3435T	71 (35.5)	54 (35)	1 (0.6–1.5)	1	21 (32)	0.8 (0.5–1.5)	0.65
HWE p	0.25	0.32			0.69

HWE: Hardy-Weinberg Equilibrium; CD: Crohn disease; UC: ulcerative colitis; OR: odds ratio; : number; CC: homozygous wild type; CT: heterozygous; TT: homozygous variant.