Genetic Polymorphisms of Multidrug Resistance Gene-1 (MDR1/ABCB1) and Glutathione S-Transferase Gene and the Risk of Inflammatory Bowel Disease among Moroccan Patients

Table 5

Distribution of genetic models of MDR1 polymorphisms in IBD patients and controls.

Genotypes/alleles	Control	CD	OR	P value	UC	OR	P value
	(%)	(%)	(95% CI)		(%)	(95% CI)
1236CC/CT	92 (92)	75 (97.5)	Ref.		25 (76)	Ref.
1236TT	8 (8)	2 (2.5)	0.3 (0.06–1.5)	0.2	8 (24)	3.7 (1.3–10.7)	0.03
1236CC	43 (43)	33 (43)	Ref.		12 (36)	Ref.
1236CT/TT	57 (57)	44 (57)	1 (0.5–1.8)	1	21(64)	1.3 (0.6–2.9)	0.5
3435CC/CT	90 (90)	70 (91)	Ref.		29 (88)	Ref.
3435TT	10 (10)	7 (9)	1 (0.3–2.5)	1	4 (12)	1.2 (0.4–4.3)	0.7
3435CC	39 (39)	30 (39)	Ref.		16 (48)	Ref.
3435CT/TT	61 (61)	47 (61)	1 (0.5–1.8)	1	17 (52)	0.7 (0.31–1.5)	0.42

Recessive model; dominant model; CD: Crohn disease; UC: ulcerative colitis; OR: odds ratio; : number; CC: homozygous wild type; CT: heterozygous; TT: homozygous variant.