Mediators of Inflammation / 2015 / Article / Tab 8 / Research Article
Genetic Polymorphisms of Multidrug Resistance Gene-1 (MDR1/ABCB1 ) and Glutathione S-Transferase Gene and the Risk of Inflammatory Bowel Disease among Moroccan Patients Table 8 Genotypic distribution of GSTM1 and GSTT1 with respect to smoking status and CD behavior.
Parameters GSTM1 nullGSTM1 presentGSTT1 nullGSTT1 presentCD behavior (%) Inflammatory 14 (63.6) 8 (36.4) 4.2 0.12 3 (13.6) 19 (86.4) 7.7 0.02 Stricturing 16 (64) 9 (36) 13 (52) 12 (48) Penetrating 12 (40) 18 (60) 10 (33.3) 20 (66.7) Smoking status (%) Crohn’s disease patients Yes (current/former) 15 (55.6) 12 (44.4) 0.02 1 9 (33.3) 18 (66.7) 0.003 1 No (never) 27 (54) 23 (46) 17 (34) 33 (66) Ulcerative colitis patients Yes (current/former) 7 (77.8) 2 (22.2) 1.5 0.26 4 (44.4) 5 (55.6) 0.02 1 No (never) 13 (54.2) 11 (45.8) 10 (41.7) 14 (58.3)
GSTM1 null: deleted glutathione S-transferase mu 1 gene; GSTM1 present: functional glutathione S-transferase mu 1 gene; GSTT1 null: deleted glutathione S-transferase theta 1 gene; GSTT1 present: functional glutathione S-transferase theta 1 gene.