Genetic Polymorphisms of Multidrug Resistance Gene-1 (MDR1/ABCB1) and Glutathione S-Transferase Gene and the Risk of Inflammatory Bowel Disease among Moroccan Patients

Table 8

Genotypic distribution of GSTM1 and GSTT1 with respect to smoking status and CD behavior.

Parameters	GSTM1 null	GSTM1 present			GSTT1 null	GSTT1 present
CD behavior (%)
Inflammatory	14 (63.6)	8 (36.4)	4.2	0.12	3 (13.6)	19 (86.4)	7.7	0.02
Stricturing	16 (64)	9 (36)			13 (52)	12 (48)
Penetrating	12 (40)	18 (60)			10 (33.3)	20 (66.7)
Smoking status (%)
Crohn’s disease patients
Yes (current/former)	15 (55.6)	12 (44.4)	0.02	1	9 (33.3)	18 (66.7)	0.003	1
No (never)	27 (54)	23 (46)			17 (34)	33 (66)
Ulcerative colitis patients
Yes (current/former)	7 (77.8)	2 (22.2)	1.5	0.26	4 (44.4)	5 (55.6)	0.02	1
No (never)	13 (54.2)	11 (45.8)			10 (41.7)	14 (58.3)

GSTM1 null: deleted glutathione S-transferase mu 1 gene; GSTM1 present: functional glutathione S-transferase mu 1 gene; GSTT1 null: deleted glutathione S-transferase theta 1 gene; GSTT1 present: functional glutathione S-transferase theta 1 gene.