LPA Promotes T Cell Recruitment through Synthesis of CXCL13

Figure 1

Effect of LPA on CXCL13 secretion in the murine air pouch with or without TNF-α pretreatment. (a) Six-day-old air pouches were produced in the dorsal skin of mice and injected with TNF-α or the vehicle for 16 h prior to stimulation with LPA for 2 h. The nontreated (NT) group was injected with vehicle only (PBS-BSA). The air pouch exudates () were collected and pooled for qualitative analysis of cytokine/chemokine secretion using the Proteome Profiler Mouse Antibody Array Panel (a). (b) Normalized data representing CXCL13 pixel density are the mean from two independent experiments.

(a)

(b)